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Gentler treatment eliminates early deaths for children with relapsed leukaemia

30 Apr 2026, 9:58 a.m.

A groundbreaking national study led by clinicians at Great Ormond Street Hospital (GOSH) has shown that children and young people with relapsed acute lymphoblastic leukaemia (ALL) can be treated safely with significantly less intensive chemotherapy.

Fluorescent microscopic image showing a dense layer of brightly coloured cells, with blue and yellow nuclei surrounded by an intricate network of red and green cell borders

Better understanding leukaemia for children with down syndrome

7 May 2026, 2:16 p.m.

Researchers have mapped the evolution of a type of leukaemia that is exclusive to children with Down syndrome and may have identified an overarching weakness in the cancer's genetic makeup.

Two pictures side by side - one is a man in glasses smiling at the camera, the other is a woman with medium brown hair.

Spotlight on our Research Co-ordinators

13 May 2026, 3:12 p.m.

Meet the staff who keep clinical trials on track, ensure the data is up-to-date, that rules are followed and families get their agreed upon support.

Woman with brown hair sat on white sofa in black and white spotted dress with cartoon space characters in the background

Professor Helen Cross elected to the Academy of Medical Sciences

8 Jun 2026, 5:39 p.m.

Professor Helen Cross, Paediatric Neurology Consultant at GOSH and Director of the UCL Great Ormond Street Institute of Child Health, has been elected to the prestigious Academy of Medical Sciences.

A woman in glasses smiles broadly at the camera while holding up a box with a large silver medal inside.

Professor Jugnoo Rahi awarded prestigious Bowman Medal by the Royal College of Ophthalmologists

10 Jun 2026, 11:41 a.m.

The Bowman Medal is the most senior honour bestowed by the College.

Image of an MRI result displaying the front and side of a skull in black and white

Researchers identify brain network linked to deadliest childhood brain cancer

15 Jun 2026, 2:25 p.m.

Researchers at GOSH and University College London have identified a human brain network associated with survival in children with diffuse midline glioma, the deadliest childhood brain cancer.

A group of people stand posed for the camera, smiling broadly.

UK-wide excellence in paediatrics

15 Jun 2026, 2:42 p.m.

Through the Paediatric Excellence Initiative, the NIHR GOSH Biomedical Research Centre is building a connected, collaborative UK-wide system to accelerate paediatric research.

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8 years of advancing care through data and innovation

17 Jun 2026, 11:32 a.m.

We have published a new booklet showcasing how our Data Research, Innovation and Virtual Environments (DRIVE) unit is using data and technology to transform care for children and young people at Great Ormond Street Hospital (GOSH).

A view from above of adult hands playing with some scientific models and the top of a child's head. The child has bright white hair and is wearing a lab coat. You can't see their faces

Shaping better research from the start

22 Jun 2026, 4:12 p.m.

At GOSH, patient and public involvement is helping researchers to ask the right question, right from the start.

a close-up view of several adjustable laboratory pipettes in a holder, with lab containers in the background.

Gene therapy successfully treats deadly childhood liver disease in mice

29 Jun 2026, 11:16 a.m.

Researchers at GOSH and UCL have used a new gene therapy to successfully treat a deadly childhood liver disease in mice.

Three people in white lab coats stand in a modern laboratory, viewed through a glass wall, facing a long bench lined with automated equipment, monitors, bottles, and pipetting machines.

World-first gene therapy to target devastating rare immune disorder

29 Jun 2026, 11:16 a.m.

A first-of-its-kind gene therapy to treat people with CTLA-4 insufficiency is being advanced through a collaboration supported by LifeArc, and developed by scientists at UCL, with manufacturing support from NHS Blood and Transplant and GOSH.

A man holding a microphone is giving a presentation in front of some equipment

A catalyst to unlock the next generation of research leaders

22 Jul 2026, 4:46 p.m.

The NIHR GOSH Biomedical Research Centre (BRC) Fellowships are transforming early-career researchers into independent leaders - driving innovation, attracting millions in funding and shaping the future of paediatric science.

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Junior researchers are crucial to the future of paediatric research

4 Aug 2026, 4:46 p.m.

Junior researchers are central to the success and sustainability of paediatric research at GOSH and the University College London Institute of Child Health.

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Building the next generation of paediatric research leaders

17 Aug 2026, 3:32 p.m.

From early career clinicians to emerging scientists, the NIHR GOSH Biomedical Research Centre (BRC)’s Academic Training Weekend is shaping the future of paediatric research - bringing together talent, expertise and ambition from across the UK.

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From complex science to clear communication

2 Jul 2026, 11:03 a.m.

Across multiple projects at GOSH, patients, families and young people are playing a vital role in transforming how research is communicated

A lady in a wheelchair wearing. She is surrounded by six men and women, and a young girl who wearing a blue top.

Landmark decision to screen for spinal muscular atrophy at birth

16 Jul 2026, 3:05 p.m.

Great Ormond Street Hospital (GOSH) is delighted at the announcement that newborn babies in England will be offered screening for spinal muscular atrophy (SMA) through the newborn blood spot, or "heel prick", test programme.

Young boy lying on front wearing a party hat with number 1 on it, smiling, with medical tube in nose.

Celebrating 25 years of saving children’s lives with gene therapy

23 Jul 2026, 11:43 a.m.

Marking 25 years since delivering the first ground-breaking gene therapy here at GOSH, having now treated more than 135 children with rare and life-threatening conditions across the world.

Illustration of healthcare professional using a computer and a child with a cochlear implant. There are numbers leaving the computer that represent data.

Building trust in data and research

28 Jul 2026, 12:50 p.m.

At GOSH, patients and young people are helping researchers understand not just what data can do, but how it should (and shouldn’t) be used, explained and protected.

A woman in a headscarf gestures towards some micro-gardens with a group of children looking on

Creating communities and lasting involvement

6 Aug 2026, 1 p.m.

At GOSH, patient and public involvement and engagement (PPIE) builds lasting relationships and communities that shape research over time.

First UK baby receives pioneering surgery in the womb for rare bowel condition

3 Aug 2026, 8 a.m.

A baby boy has become the first child in the UK to undergo pioneering surgery while still in the womb for gastroschisis.

Gentler treatment eliminates early deaths for children with relapsed leukaemia

Better understanding leukaemia for children with down syndrome

Spotlight on our Research Co-ordinators

Professor Helen Cross elected to the Academy of Medical Sciences

Professor Jugnoo Rahi awarded prestigious Bowman Medal by the Royal College of Ophthalmologists

Researchers identify brain network linked to deadliest childhood brain cancer

UK-wide excellence in paediatrics

8 years of advancing care through data and innovation

Shaping better research from the start

Gene therapy successfully treats deadly childhood liver disease in mice

World-first gene therapy to target devastating rare immune disorder

A catalyst to unlock the next generation of research leaders

Junior researchers are crucial to the future of paediatric research

Building the next generation of paediatric research leaders

From complex science to clear communication

Landmark decision to screen for spinal muscular atrophy at birth

Celebrating 25 years of saving children’s lives with gene therapy

Building trust in data and research

Creating communities and lasting involvement

First UK baby receives pioneering surgery in the womb for rare bowel condition

World-first gene therapy to target devastating rare immune disorder