Search

Patient wearing jeans and a t-shirt holding a birthday balloon and 10 balloon

Gentler treatment eliminates early deaths for children with relapsed leukaemia

30 Apr 2026, 9:58 a.m.

A groundbreaking national study led by clinicians at Great Ormond Street Hospital (GOSH) has shown that children and young people with relapsed acute lymphoblastic leukaemia (ALL) can be treated safely with significantly less intensive chemotherapy.

Fluorescent microscopic image showing a dense layer of brightly coloured cells, with blue and yellow nuclei surrounded by an intricate network of red and green cell borders

Better understanding leukaemia for children with down syndrome

7 May 2026, 2:16 p.m.

Researchers have mapped the evolution of a type of leukaemia that is exclusive to children with Down syndrome and may have identified an overarching weakness in the cancer's genetic makeup.

Two pictures side by side - one is a man in glasses smiling at the camera, the other is a woman with medium brown hair.

Spotlight on our Research Co-ordinators

13 May 2026, 3:12 p.m.

Meet the staff who keep clinical trials on track, ensure the data is up-to-date, that rules are followed and families get their agreed upon support.

Woman with brown hair sat on white sofa in black and white spotted dress with cartoon space characters in the background

Professor Helen Cross elected to the Academy of Medical Sciences

8 Jun 2026, 5:39 p.m.

Professor Helen Cross, Paediatric Neurology Consultant at GOSH and Director of the UCL Great Ormond Street Institute of Child Health, has been elected to the prestigious Academy of Medical Sciences.

A woman in glasses smiles broadly at the camera while holding up a box with a large silver medal inside.

Professor Jugnoo Rahi awarded prestigious Bowman Medal by the Royal College of Ophthalmologists

10 Jun 2026, 11:41 a.m.

The Bowman Medal is the most senior honour bestowed by the College.

Image of an MRI result displaying the front and side of a skull in black and white

Researchers identify brain network linked to deadliest childhood brain cancer

15 Jun 2026, 2:25 p.m.

Researchers at GOSH and University College London have identified a human brain network associated with survival in children with diffuse midline glioma, the deadliest childhood brain cancer.

A group of people stand posed for the camera, smiling broadly.

UK-wide excellence in paediatrics

15 Jun 2026, 2:42 p.m.

Through the Paediatric Excellence Initiative, the NIHR GOSH Biomedical Research Centre is building a connected, collaborative UK-wide system to accelerate paediatric research.

Hands in front of a virtual reality screen

8 years of advancing care through data and innovation

17 Jun 2026, 11:32 a.m.

We have published a new booklet showcasing how our Data Research, Innovation and Virtual Environments (DRIVE) unit is using data and technology to transform care for children and young people at Great Ormond Street Hospital (GOSH).

A view from above of adult hands playing with some scientific models and the top of a child's head. The child has bright white hair and is wearing a lab coat. You can't see their faces

Shaping better research from the start

22 Jun 2026, 4:12 p.m.

At GOSH, patient and public involvement is helping researchers to ask the right question, right from the start.

a close-up view of several adjustable laboratory pipettes in a holder, with lab containers in the background.

Gene therapy successfully treats deadly childhood liver disease in mice

29 Jun 2026, 11:16 a.m.

Researchers at GOSH and UCL have used a new gene therapy to successfully treat a deadly childhood liver disease in mice.

Three people in white lab coats stand in a modern laboratory, viewed through a glass wall, facing a long bench lined with automated equipment, monitors, bottles, and pipetting machines.

World-first gene therapy to target devastating rare immune disorder

29 Jun 2026, 11:16 a.m.

A first-of-its-kind gene therapy to treat people with CTLA-4 insufficiency is being advanced through a collaboration supported by LifeArc, and developed by scientists at UCL, with manufacturing support from NHS Blood and Transplant and GOSH.

A close up image of a vial of liquid with a blurry outline of the man holding it behind

From complex science to clear communication

2 Jul 2026, 11:03 a.m.

Across multiple projects at GOSH, patients, families and young people are playing a vital role in transforming how research is communicated

Unidentified person cutting out letters for an arts project, May 2017

Good Hope Works at GOSH

17 May 2017, 12:53 p.m.

Good Hope Works is an exciting creative research project facilitated by GOSH Arts and undertaken by artist Joanna Brinton. The project has engaged staff from across Great Ormond Street Hospital (GOSH) and will culminate in the installation of a permanent

£1 million award to push forward regenerative medicine research

13 Dec 2018, 10:19 a.m.

Researchers at Great Ormond Street Hospital (GOSH) and the UCL Great Ormond Street Institute of Child Health (ICH) are to lead a new collaboration exploring how stem cells can be engineered to evade immune responses.

AI bodysuit trial launched to help treat Duchenne muscular dystrophy

1 Feb 2018, 11:57 a.m.

A new artificially intelligent bodysuit to help understand how mobility is affected in boys with Duchenne will be trialled in a collaboration between researchers at Great Ormond Street Hospital (GOSH) and Imperial College London.

A liquid handling robot appears placing ampules into laboratory trays.

BRC researchers part of collaboration to improve efficiency of gene therapy products

26 Jul 2018, 3:56 p.m.

A new collaboration aiming to develop advanced technologies for manufacturing ex vivo gene therapy products has been established between researchers at UCL Great Ormond Street Institute of Child Health (ICH) and Plasticell, a developer of stem cell techno

Meredyth Wilkinson, one of the study's first authors

Cutting edge new method reveals novel cause of Juvenile dermatomyositis

25 Jun 2018, 10:18 a.m.

A new in-depth method has helped shed light on the key role of B cells, a type of immune cell, in the rare childhood condition Juvenile dermatomyositis (JDM).

Driving forward medical device development

2 Oct 2019, 4:57 p.m.

The NIHR GOSH BRC last month hosted an inaugural medical devices workshop, in partnership with the UCL Institute of Healthcare Engineering.

Drug for Duchenne Muscular Dystrophy shows promise in clinical trial

21 Aug 2017, 12:02 p.m.

An international clinical trial has found that the drug ataluren can improve mobility for children with a severe form of Duchenne muscular dystrophy (DMD).

Film celebrates success of Biomedical Research Centres set up by outgoing UK Chief Medical Officer

14 Oct 2019, 11:37 a.m.

NHS patients who have taken part in clinical trials have expressed their gratitude to researchers in a film celebrating the work of the National Institute for Health Research (NIHR) Biomedical Research Centres (BRCs), including GOSH BRC, to mark the retir

Gentler treatment eliminates early deaths for children with relapsed leukaemia

Better understanding leukaemia for children with down syndrome

Spotlight on our Research Co-ordinators

Professor Helen Cross elected to the Academy of Medical Sciences

Professor Jugnoo Rahi awarded prestigious Bowman Medal by the Royal College of Ophthalmologists

Researchers identify brain network linked to deadliest childhood brain cancer

UK-wide excellence in paediatrics

8 years of advancing care through data and innovation

Shaping better research from the start

Gene therapy successfully treats deadly childhood liver disease in mice

World-first gene therapy to target devastating rare immune disorder

From complex science to clear communication

Good Hope Works at GOSH

£1 million award to push forward regenerative medicine research

AI bodysuit trial launched to help treat Duchenne muscular dystrophy

BRC researchers part of collaboration to improve efficiency of gene therapy products

Cutting edge new method reveals novel cause of Juvenile dermatomyositis

Driving forward medical device development

​Drug for Duchenne Muscular Dystrophy shows promise in clinical trial

Film celebrates success of Biomedical Research Centres set up by outgoing UK Chief Medical Officer

World-first gene therapy to target devastating rare immune disorder

Drug for Duchenne Muscular Dystrophy shows promise in clinical trial