Conditions treated by the Immunology department

Conditions treated by the Immunology department at Great Ormond Street Hospital (GOSH) include:

Severe immunodeficiencies for which stem cell transplantation or gene therapy may be appropriate

*All infants affected by SCID require corrective therapy. For all other disorders each child is individually assessed regarding the need for transplantation/gene therapy.

Primary immunodeficiencies not requiring transplantation

  • common variable immunodeficiency (CVID)
  • X-linked agammaglobulinemia (XLA)
  • transient hypogammaglobulinemia of infancy
  • selective IgA deficiency
  • IgG subclass deficiency (usually associated with IgA deficiency)
  • C1 esterase inhibitor deficiency (hereditary angioedema)
  • hyper-IgE syndrome (Job’s syndrome)
  • other neutrophil disorders
  • ataxia telangiectasia

Other immunological disorders

  • periodic fever syndromes
  • vasculitis
  • autoimmune lymphoproliferative syndrome

Management guidelines

A range of management guidelines have been prepared by the UK-Primary Immunodeficiency Network.