A cleft is a hole or gap affecting the tissues in the palate (roof of the mouth). This information sheet from Great Ormond Street Hospital (GOSH) explains the symptoms, causes and treatment of cleft palate and where to get help.
Treacher-Collins syndrome (also known as mandibulofacial dysostosis) is a congenital (present at birth) condition affecting the bones and tissues in the face. This page from Great Ormond Street Hospital (GOSH) explains the causes, symptoms and treatment o
Neuromyelitis optica spectrum disorder (NMOSD) is a rare neurological (brain) condition characterised by episodes of optic neuritis (inflammation or swelling of the optic nerve), transverse myelitis (inflammation or swelling of the spinal cord), together
New trial to support childhood survivors of brain tumours
19 Feb 2026, 9:33 a.m.
Experts at Great Ormond Street Hospital have launched the first trial of its kind to support children’s cognitive development following treatment for a brain tumour.
GOSH celebrates Rare Disease Day 2026 with local community
16 Mar 2026, 11:25 a.m.
GOSH specialises in rare disease research and to celebrate, we recently invited two local North London Year 4 classes to join us for the day to learn about how we care for patients with rare diseases.
This page from Great Ormond Street Hospital (GOSH) explains the neurological condition Vein of Galen Malformation (VGM). It aims to help understanding the condition, how it can be treated and what to expect when a child is admitted to GOSH.
Congenital hypothyroidism is a disorder affecting the thyroid gland, which is in the neck. The thyroid gland produces a hormone (chemical substance) called thyroxine, which is needed for normal growth and development.
Multiple sclerosis (MS) is a common neurological condition affecting around 100,000 adults in the UK, but it is rare in childhood – and particularly rare in children under 12. This page from Great Ormond Street Hospital (GOSH) describes the symptoms, caus
Septicaemia is another term used to describe blood poisoning. It is an infection caused by large amounts of bacteria entering the bloodstream. It is a potentially life-threatening infection that affects thousands of patients every year.
Saethre-Chotzen syndrome is a type of complex craniosynostosis named after the two doctors who described it in the mid-20th century. This page from Great Ormond Street Hospital (GOSH) explains the causes, symptoms and treatment of Saethre-Chotzen syndrome
Cranio-fronto-nasal dysplasia is a type of craniosynostosis. The name describes the parts of the skull and face affected. This page from Great Ormond Street Hospital (GOSH) explains the causes, symptoms and treatment of cranio-fronto-nasal dysplasia (also
Carpenter syndrome is a type of craniosynostosis named after the doctor who first described the condition. This page from Great Ormond Street Hospital (GOSH) explains the causes, symptoms and treatment of Carpenter syndrome (also known as acrocephalopolys
Researchers identify brain network linked to deadliest childhood brain cancer
15 Jun 2026, 2:25 p.m.
Researchers at GOSH and University College London have identified a human brain network associated with survival in children with diffuse midline glioma, the deadliest childhood brain cancer.
