https://www.gosh.nhs.uk/our-people/staff-z/mehul-dattani/

Mehul Dattani

Professor Mehul Dattani is currently Head of Paediatric Endocrinology at Great Ormond Street Hospital for Children (GOSH), University College London Hospitals (UCLH) and Institute of Child Health (ICH).

He has an active clinical practice encompassing all areas of paediatric and adolescent endocrinology at GOSH and UCLH.

Specialisms

General paediatric endocrinology with an interest in hypopituitarism, disorders of growth, and disorders of sex development.

Endocrinology information

Qualifications

MBBS DCH FRCPCH FRCP MD

Professor Dattani qualified in Medicine at the Middlesex Hospital, London. He trained in paediatric endocrinology and was awarded an MD at UCL for his work on the optimization of a novel bioassay for the estimation of serum growth hormone (GH). He then obtained post-doctoral experience at the Medical Research Council (MRC) National Institute for Medical Research where he identified the first gene to be associated with septo-optic dysplasia. Subsequently, he was appointed as a Lecturer in Paediatric Endocrinology at the Institute of Child Health, promoted to Reader in 2004, and then to Professor in 2006.

He is Chair of the British Society for Paediatric Endocrinology and Diabetes (BSPED), and Chair-Elect of the Programme Organizing Committee of the European Society for Paediatric Endocrinology (ESPE), with a position on the Council of ESPE.

Research Interests

Professor Mehul Dattani is currently Clinical and Academic Lead in Paediatric and Adolescent Endocrinology at Great Ormond Street Hospital for Children (GOSH), UCLH and ICH.

His main research interest lies in the area of disorders of hypothalamo-pituitary disorders such as congenital hypopituitarism including disorders such as Septo-optic Dysplasia, tumours including craniopharyngioma, disorders of gonadotrophin secretion such as hypogonadotrophic hypoogonadism, and hypothalamic obesity.

He has identified mutations in a number of known and novel genes implicated in disorders of hypothalamo-pituitary development and hypothalamo-pituitary tumours, and his work has been recognised nationally and internationally.

His other research interests include identification of the molecular basis of rare endocrine disorders affecting the thyroid, adrenals and gonads.

References:

1.Gaston-Massuet C, Andoniadou CL, Signore M, Jayakody SA, Charolidi N, Kyeyune R, Vernay B, Jacques TS, Taketo MM, Le Tissier P, Dattani MT, Martinez-Barbera JP (2011) Increased Wingless (Wnt) signaling in pituitary progenitor/stem cells gives rise to pituitary tumors in mice and humans. Proc Natl Acad Sci USA 108(28): 11482-7.

2.McCabe MJ, Gaston-Massuet C, Tziaferi V, Gregory LC, Alatzoglou KS, Signore M, Puelles E, Gerrelli D, Farooqi IS, Raza J, Walker J, Kavanaugh SI, Psai PS, Pitteloud N, Martinez-Barbera JP, Dattani MT (2011) Novel FGF8 mutations associated with recessive holoprosencephaly, craniofacial defects, and hypothalamo-pituitary defects. Journal of Clinical Endocrinology and Metabolism 96(10): E1709-18.

3. Bochukova E, Schoenmakers N, Agostini N, Schoenmakers E, Rajanayagam O, Keogh JM, Henning E, Reinemund J, Gevers E, Sarri M, Downes K, Offiah A, Albanese A, Halsall D, Schwabe J, Bain M, Lindley K, Muntoni F, Vargha Khadem F, Dattani M, Farooqi S, Gurnell M, and Chatterjee K (2012) A mutation in the thyroid hormone receptor alpha gene. New England Journal of Medicine 366(3): 243-9.

4. Webb EA, O’Reilly MA, Clayden JD, Seunarine KK, Chong WK, Dale N, Salt A, Clark CA, Dattani MT (2012) Effect of growth hormone deficiency on brain structure, motor function and cognition. Brain 135 (Part 1): 216-227.

5.Jayakody S, Andoniadou CL, Gaston-Massuet C, Signore M, Cariboni A, Bouloux PM, Le Tissier P, Pevny L, Dattani MT, Martinez-Barbera JP (2012) Severe pituitary hypoplasia and decreased GnRH neurogenesis in a mouse model of SOX2-associated hypopituitarism in humans. Journal of Clinical Investigation 122(10): 3635-46.

6.Sun Y, Bak B, Schoenmakers N, van Trotsenburg ASP, Oostdijk W, Voshol P, Cambridge E, White JK, le Tissier P, Mousavy Gharavy SN, Martinez-Barbera JP, Stokvis-Brantsma WH, Vulsma T, Kempers MJ, Persani L, Campi I, Bonomi M, Beck-Peccoz P, Zhu H, Davis TME, Hokken-Koelega ACS, Del Blanco DG, Rangasami JJ , Ruivenkamp CAL, Laros JFL, Kriek M, Kant SG, Bosch CAJ, Biermasz NR, Appelman-Dijkstra NM, Corssmit EP, Hovens GCJ, Pereira AM, den Dunnen JT, Breuning MH, Hennekam RC, Chatterjee KK*, Dattani MT*, Wit JM*, Bernard DJ* (*Co-Senior Authors) (2012) Loss-of-function mutations in IGSF1 cause a novel X-linked syndrome of central hypothyroidism and testicular enlargement Nature Genetics 44(12): 1375-1381.

7.McCabe MJ, Gaston-Massuet C, Gregory LC, Alatzoglou KS, Tziaferi V, Sbai O, Rondard P, Masumoto KH, Nagano M, Shigeyoshi Y, Pfeifer M, Hulse T, Buchanan CR, Pitteloud N, Martinez-Barbera JP, Dattani M (2013) Variations in PROKR2, but not PROK2, are associated with hypopituitarism and septo-optic dysplasia. J Clin Endocrinol Metab 98(3): E547-557.

8.Gregory LC, Gevers EF, Baker J, Kasia T, Chong K, Josifova DJ, Caimari M, Bilan F, McCabe MJ, Dattani MT (2013) Structural pituitary abnormalities associated with CHARGE Syndrome. J Clin Endocrinol Metab 98(4): E737-743.

9.Webb EA, O’Reilly MA, Clayden JD, Seunarine KK, Dale N, Salt A, Clark CA, Dattani MT (2013) Reduced ventral cingulum integrity and increased behavioral problems in children with isolated optic nerve hypoplasia and mild to moderate or no visual impairment. PLOS One 8(3): e59048.

10.Webb EA, AlMutair A, Kelberman D, Bacchelli C, Chanudet E, Lescai F, Andoniadou CL, Banyan A, Swaid A, Alrifai MT, Alahmesh MA, Balwi M, Mousavy-Gharavy SN, Lukovic B, Burke D, McCabe MJ, Kasia T, Kleta R, Stupka E, Beales PL, Thompson DA, Chong WK, Alkuraya FS, Martinez-Barbera JP, Sowden JC, Dattani MT (2013) ARNT2 mutation causes hypopituitarism, postnatal microcephaly, visual and renal anomalies. Brain (in press).

11. Andoniadou C, Matsushima D, Mousavy-Gharavy SN, Signore M, Mackintosh AI, Schaeffer M, Gaston-Massuet C, Mollard P, Jacques TS, Le Tissier P, Dattani MT, Pevny L, Martinez-Barbera JP (2013) The Sox2+ population of the adult murine pituitary includes progenitor/stem cells with tumour-inducing potential. Cell Stem Cell (in press).

Contact

Telephone: 020 7405 9200 (ext 5813)