Refer a patient to the Immunology department

The Immunology department at Great Ormond Street Hospital (GOSH) is part of the University College London (UCL) Centre for Immunodeficiency. This comprises adult and paediatric clinical services, diagnostic laboratories and research.

Please see our admission criteria for information about the diagnoses treated by the Immunology department at GOSH.

How to refer a patient

For an outpatient appointment

As a tertiary care hospital, all children who attend GOSH must be referred via local hospital consultants, community paediatricians or in certain circumstances via a GP.

To make a referral please email gos-tr.referrals@nhs.net or fax 020 7813 8310.

International referrals are also received from a variety of countries.

For urgent out-of-hours admissions please contact the GOSH switchboard on 020 7405 9200 and ask for the on-call immunology consultant.

How to get advice

For patients known to GOSH

During office hours please contact the immunology secretary on 020 7829 8834. Alternatively, contact the GOSH switchboard on 020 7405 9200 and ask for the Immunology department.

Out of hours, please contact the GOSH switchboard on 020 7405 9200 and ask for the immunology registrar.

For patients not known to GOSH

During office hours please contact the immunology secretary on 020 7829 8834. Alternatively, contact the GOSH switchboard on 020 7405 9200 and ask for the Immunology department.

Out of hours, please contact the GOSH switchboard on 020 7405 9200 and ask for the immunology registrar.

Key staff members

Consultants

  • Dr Alison Jones, Consultant Paediatric Immunologist and Honorary Senior Lecturer
    Special interest(s): X-linked Agammaglobulinemia; Common Variable Immunodeficiency; Chromosome 22q11 microdeletion syndrome
    Alison.Jones@gosh.nhs.uk

  • Dr Cathy Cale, Consultant Paediatric Immunologist, Immunopathologist and Honorary Senior Lecturer
    Special interest(s): Chediak-Higashi syndrome
    Catherine.Cale@gosh.nhs.uk

  • Professor Bobby Gaspar, GOSHCC Professor of Paediatrics and Immunology and Honorary Consultant in Paediatric Immunology
    Special interest(s): X-linked lymphoproliferative syndrome and other EBV-related PIDs; Bone marrow transplantation and gene therapy for PID
    Bobby.Gaspar@gosh.nhs.uk

  • Professor David Goldblatt, Professor of Vaccinology and Immunology and Honorary Consultant in Paediatric Immunology
    Special interest(s): Chronic Granulomatous Disease
    David.Goldblatt@gosh.nhs.uk

  • Professor Adrian Thrasher, Professor in Paediatric Immunology and Honorary Consultant Immunologist
    Special interest(s): Wiskott Aldrich syndrome; Gene therapy for PID 
    Adrian.Thrasher@gosh.nhs.uk 

  • Dr Siobhan Burns, Senior Clinical Lecturer and Honorary Consultant in Paediatric Immunology
    Siobhan.Burns@gosh.nhs.uk 

  • Dr Amel Hassan, Associate Specialist Paediatric Immunologist
    Amel.Hassan@gosh.nhs.uk

Nursing staff

  • Clare Gilmour, Immunology Nurse Specialist
    Special interest(s): Antibody deficiency and Immunoglobulin replacement therapy
    Clare.Gilmour@gosh.nhs.uk

  • Helen Braggins, Immunology Nurse Specialist
    Special interest(s): Chronic Granulomatous Disease
    Helen.Braggins@gosh.nhs.uk

  • Lucie Brown Immunology specialist nurse 
    Special interest(s): SCID and bone marrow transplantation
    Lucie.Brown@gosh.nhs.uk
  • Jinhua Xu-Bayford Immunology/Gene therapy specialist nurse
    Special interest(s): Gene therapy and bone marrow transplantation
    Jinhua.Xu-Bayford@gosh.nhs.uk

Services and facilities available

The Immunology department offers diagnosis and management of all degrees of severity of primary immunodeficiency.

The team offers inpatient, outpatient and day case services.

Services are also provided for children with a variety of other immunological disorders (excluding allergy).

Children with immunodeficiency are managed by the medical/specialist nursing team, on a shared care basis with local paediatricians, community nurses, and in some cases GPs.

The Immunology department at GOSH offers a comprehensive diagnostic and treatment service for children from birth to 16 years with suspected or confirmed primary immunodeficiency.

Severe immunodeficiencies

Severe immunodeficiencies for which stem cell transplantation or gene therapy may be appropriate:

  • all forms of severe combined immunodeficiency (SCID)*

  • other (as yet molecularly undefined) combined immunodeficiencies

  • X-linked Hyper-IgM syndrome (CD40 ligand deficiency)

  • Wiskott-Aldrich syndrome

  • X-linked lymphoproliferative syndrome

  • haemophagocytic lymphohistiocytosis

  • chronic granulomatous disease

  • Chediak-Higashi syndrome

  • leucocyte adhesion deficiencies

  • some forms of Hyper IgE

*All infants affected by SCID require corrective therapy. For all other disorders each child is individually assessed regarding the need for transplantation/gene therapy.

Primary immunodeficiencies

Primary immunodeficiencies not usually requiring transplantation:

  • common variable immunodeficiency (CVID)

  • X-linked agammaglobulinemia (XLA)

  • transient hypogammaglobulinemia of infancy

  • selective IgA deficiency

  • IgG subclass deficiency (usually associated with IgA deficiency)

  • C1 esterase inhibitor deficiency (hereditary angioedema)

  • hyper-IgE syndrome (Job’s syndrome)

  • other neutrophil disorders

  • ataxia telangiectasia

Other immunological disorders

  • periodic fever syndromes

  • vasculitis

  • autoimmune lymphoproliferative syndrome

Bone marrow transplant (BMT)

The Immunology department works in close collaboration with the BMT unit, providing one of the two supra-regionally funded UK services for BMT for severe immunodeficiency.

This is one of the largest centres for BMT for primary immunodeficiency worldwide.

Other clinics and services

There are specialist clinics for certain disorders and dedicated BMT follow-up clinics.

Joint clinics are held with several related sub specialties and outreach clinics are held in a number of other centres.

For children requiring replacement immunoglobulin we work closely with local teams to either train parents to administer treatment at home, or for it to be provided close to home in local hospitals.

There is a dedicated nurse for this service.

Feedback and suggestions

All general feedback and suggestions can be directed to:

Immunology Secretary
West Link Corridor
Great Ormond Street Hospital
Great Ormond Street
London
WC1N 3JH

Telephone number: 020 7829 8834/7813/8121
Fax number: 020 7813 8552

Management contacts

Professor Bobby Gaspar
Specialty Lead for Immunology
Bobby.Gaspar@gosh.nhs.uk

Sarah Lewis
Service Manager
020 7405 9200 Ext 5096
Sarah.Lewis@gosh.nhs.uk

Carla Hobart
General Manager
020 7405 9200 Ext 1008
Carla.Hobart@gosh.nhs.uk

Special interest(s): BMT; Cellular therapies