Research conducted within the Perfusion service

The Perfusion Department is involved in a broad range of research both ongoing and published.

The following list are those that have been published

  1. Wiggins, L.M., Mimic, B., Issitt, R., Ilic, S., Bonello, B., Marek, J., Kostolny, M. The Utility of Aortic Valve Leaflet Reconstruction Techniques in Children and Young Adults. 2019. JTCVS. In print.

  2. Crook R, Wheeler K. Falsely low activated clotting time measured in a patient with sickle cell trait. Perfusion. 2019 May;34(4):334-336.

  3. Adekoya T, Rogers Y, Issitt R, Sebire NJ. An exploration of a clinical decision support system for perfusionists. Arch Dis Child 2018; 103: suppl2; 61.

  4. Aiyer S, Issitt R, Rogers Y, Sebire, NJ. 134 Research and design for cardiac perfusion – visualisation of data ‘quality markers’ Arch Dis Child 2018; 103: A54.

  5. Robertson A, Hsia TY. An Adverse Event Analysis: Inadvertent Exsanguination Following Left Ventricular Assist Device Implantation in a Child. Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu. 2018 Mar;21:15-18.

  6. Muthialu N, Robertson A, Mortensen K, Khambadkone S. Case report on surgical repair of unusual dissection of arterial duct involving main pulmonary artery in a child with vein of Galen malformation. Eur Heart J Case Rep. 2018 Nov 24;2(4):yty140.

  7. Crook, R., and Issitt, R. Cardiopulmonary Bypass for a Patient with Congenital Hyperinsulinemia. WJPCHS 2018 Jan 1:2150135117742649. doi: 10.1177/2150135117742649. [Epub ahead of print]

  8. Robertson, A., Issitt, R., Crook, R., Gustafsson, K., Eddaoudi, A., Tsang, T., and Burch, M. A Novel Method for ABO Incompatible Heart Transplantation. The Journal of Heart and Lung Transplantation 2018: 37(4) 451-457.

  9. Robertson A, Issitt R, Crook R, et al. D2.3 An ex-vivo model for the incorporation of immunoadsorption into the extracorporeal circuit: a novel method for abo incompatible heart transplantation. Archives of Disease in Childhood 2017;102:A13-A14.

  10. Richardson, R., Issitt, R., and Crook, R. Beta-Thalassemia in the Paediatric Cardiac Surgery Setting - a Case Report and Literature Review. Perfusion 2017; 33(3): 232-234.

  11. Issitt, R., Ball, J., Bilhkoo, I., Mani, A., Walsh, B., and Voegeli, D. Leucocyte Filtration of the Cardiotomy Suction. Does it affect Systemic Leucocyte Activation or Pulmonary Function? Perfusion. 2017: 32(7) 574–582.

  12. Issitt, R., James, T., Walsh, B., and Voegeli, D. Do Lipid Microemboli Induce Acute Kidney Injury during Cardiopulmonary Bypass? Perfusion 2017; 32(6): 466–473.

  13. Issitt, R., Harvey, I., Walsh, B., and Voegeli, D. Quantification of lipid filtration and the effects on cerebral injury during cardiopulmonary bypass. Ann Thorac Surg 2017; 104: 884-890.

  14. Crook, R., and Issitt, R. Oncotic pressure and paediatric cardiopulmonary bypass: establishing baseline data for complex congenital cardiac surgery and its relation to risk stratification. Perfusion 2017; 35(2): 378-382.

  15. Issitt, R. Invited Commentary on: Effect of cardiopulmonary bypass on platelet mitochondrial respiration and correlation with aggregation and bleeding: a pilot study. Perfusion 2016; 31: 516-7.

  16. Issitt, R., Crook, R, Robertson, A., Shaw, M., and Tsang, V. Conclusions from in vitro vs. in vivo data. Perfusion 2015; 30(2):174-5.

  17. Issitt, R.W., Robertson, D.A., Crook, R.M., Cross, N.T., Shaw, M., and Tsang, V.T. Tetralogy of Fallot with pulmonary atresia and major aortopulmonary collateral vessels. Perfusion 2014; 29:567.

  18. Issitt, R., Robertson, A., Cross, N, Crook, R., Molyneux, V., Walton, N and Tsang, V. Clinical experience with Affinity Pixie™ oxygenation system in paediatric and infant patients. Perfusion 2014;29(3):194-8.

  19. Issitt, R., Sheppard S., Voegeli, D., and Walsh B. Design of a Prospective Clinical Study on the Quantification of Lipid and Leucocyte Filtration and the Effects on Cerebral and Renal Injury Markers and Pulmonary Function during Cardiopulmonary Bypass. Working Papers in Health Sciences 1:6 Winter ISSN 2051-6266 / 20140034.

  20. Issitt, R.W., Crook, R.M, Cross, N.T., Shaw, M., Burch, M, Hsia, T.Y., and Tsang, V.T. ABO-incompatible plasma exchange: Lessons from evolving practice. Perfusion 2012;27(6):480-5.

  21. Harban FM, Connor P, Crook R, Bingham R. Cardiopulmonary bypass for surgical correction of congenital heart disease in children with sickle cell disease: a case series. Anaesthesia. 2008 Jun;63(6):648-51.

  22. Karimova A, Robertson A, Cross N, Smith L, O'callaghan M, Tuleu C, Long P, Beeton A, Han J, Ridout D, Goldman A, Brown K. A wet-primed extracorporeal membrane oxygenation circuit with hollow-fiber membrane oxygenator maintains adequate function for use during cardiopulmonary resuscitation after 2 weeks on standby. Crit Care Med. 2005 Jul;33(7):1572-6.