A cleft is a hole or gap affecting the tissues in the lip. This information sheet from Great Ormond Street Hospital (GOSH) explains the causes, symptoms and treatment of cleft lip and where to get help.
New VR game to help children rehabilitate after brain tumour treatment
15 May 2025, 1:28 p.m.
The National Institute for Health and Care Research Great Ormond Street Hospital Biomedical Research Centre (NIHR GOSH BRC) is working with partners to develop a new virtual reality (VR) game.
World-first gene therapy to target devastating rare immune disorder
29 Jun 2026, 11:16 a.m.
A first-of-its-kind gene therapy to treat people with CTLA-4 insufficiency is being advanced through a collaboration supported by LifeArc, and developed by scientists at UCL, with manufacturing support from NHS Blood and Transplant and GOSH.
CLOSED: To support early career researchers to undertake a placement at an external research institute to facilitate the transfer of knowledge around a new key technology or technique, and to strengthen collaborations or develop new partnerships.
NIHR GOSH BRC Career Development Academy Knowledge Transfer Scheme 2025
CLOSED: This call aimed to support early career researchers to undertake a research placement at external institutes to learn key technologies or techniques.
The NIHR Great Ormond Street Hospital Biomedical Research Centre (NIHR GOSH BRC) will be supporting research projects across the Accelerating Novel Therapies (ANT) theme and the wider BRC and research community, through the generation of CRISPR-gene…
Closed: The Catalyst Fellowship 2026 is open for applications. The Fellowship aims to build the capacity of child health researchers to enable them to take the next step in their career and become the future leaders in child health research.
Genetic testing helps diagnose developmental disorders before birth
1 Feb 2019, 11:05 a.m.
Genetic sequencing improved the diagnosis of abnormalities detected in ultrasound scans of developing babies, in new research from Great Ormond Street Hospital (GOSH), the Wellcome Sanger Institute and Birmingham Women’s Hospital.
Research successes highlighted at BRC showcase event
16 Apr 2019, 4:27 p.m.
Over 150 people came along to the National Institute for Health Research (NIHR) GOSH Biomedical Research Centre showcase last month to hear about our latest research highlights - from cutting edge CAR-T therapies for leukaemia, to Oculome genomic sequenci
MRI scans more precisely define and detect some abnormalities in unborn babies
17 Mar 2021, 10:57 a.m.
MRI scanning can more precisely define and detect head, neck, thoracic, abdominal and spinal malformations in unborn babies, finds a large multidisciplinary study led by Evelina London Children’s Hospital, Great Ormond Street Hospital and UCL.
To celebrate Rare Disease Day we invited patients and their families to try out 13 different hands-on and interactive fun and educational science and research activities for children and adults.
A story running across BBC channels today featuring four GOSH families has accused the hospital of not being transparent, covering up when things have gone wrong and failing to learn from mistakes.
These allegations are very serious and we strongly refut
NIHR GOSH BRC Career Development Academy Knowledge Transfer Scheme 2024
CLOSED: This call aims to support early career researchers to undertake a research placement at external institutes to learn key technologies or techniques.
First children receive a genetic diagnosis at GOSH as part of the 100,000 Genomes Project
11 Jan 2016, 5:46 p.m.
The first children to receive a genetic diagnosis through the 100,000 Genomes Project have been given their results at Great Ormond Street Hospital (GOSH), part of the North Thames Genomic Medical Centre (NTGMC.)
Cleft palate repair is an operation to repair defects of the hard and soft palate. This page explains about the operation to repair a cleft palate and what to expect when your child comes to the North Thames Cleft Service for the operation.
