Tissue engineering and regenerative medicine

Tissue engineering and regenerative medicine

Theme Leads: Professor Jane Sowden and Professor Paolo De Coppi

Junior Faculty Representatives: Dr Jennie Chandler and Dr Gabriel Galea

Research Theme Manager: Valerija Karaluka

The Tissue engineering and regenerative medicine theme builds on expertise in stem cell research and regenerative medicine.

Among other ground-breaking projects, researchers in the theme are able to use stem cells to:

  • Develop models of disease called 'organoids' that act as lab-versions of human organs and disease.
  • Study biomaterials that can mimic and support human tissue.
  • Use bioengineering and surgical innovations to tackle congenital structural defects and organ replacement.

Successful projects that have made their way to patients include bioengineered trachea and thymus transplantation, world-first alloys for minimally-invasive skull surgery and UK-first fetal surgery for spina bifida. The team are already progressing to minimally-invasive fetoscopic surgery in formal clinical trials and exploring how this technology can be applied to other conditions that affect the diaphragm and lungs.

Latest research