https://www.gosh.nhs.uk/our-research/our-research-infrastructure/nihr-great-ormond-street-hospital-brc/about-our-biomedical-research-centre/our-research-themes/tissue-engineering-and-regenerative-medicine/
Tissue engineering and regenerative medicine
Theme Leads: Professor Jane Sowden and Professor Paolo De Coppi
Junior Faculty Representatives: Dr Jennie Chandler and Dr Gabriel Galea
Research Theme Manager: Valerija Karaluka
The Tissue engineering and regenerative medicine theme builds on expertise in stem cell research and regenerative medicine.
Among other ground-breaking projects, researchers in the theme are able to use stem cells to:
- Develop models of disease called 'organoids' that act as lab-versions of human organs and disease.
- Study biomaterials that can mimic and support human tissue.
- Use bioengineering and surgical innovations to tackle congenital structural defects and organ replacement.
Successful projects that have made their way to patients include bioengineered trachea and thymus transplantation, world-first alloys for minimally-invasive skull surgery and UK-first fetal surgery for spina bifida. The team are already progressing to minimally-invasive fetoscopic surgery in formal clinical trials and exploring how this technology can be applied to other conditions that affect the diaphragm and lungs.