https://www.gosh.nhs.uk/our-people/staff-z/stephen-marks/

Stephen Marks

Stephen Marks - Nephrology team

Professor Stephen Marks, MD MSc MRCP DCH FRCPCH is a Consultant Paediatric Nephrologist and Clinical Lead for renal transplantation at Great Ormond Street Hospital (GOSH) which is the largest kidney transplantation unit in the United Kingdom for children and young people. He is Professor of Paediatric Nephrology and Transplantation at University College London Great Ormond Street Institute of Child Health and Director of the NIHR GOSH Clinical Research Facility.

He is theme lead for high intensity early phase clinical trials as well as PPIEP for NIHR GOSH Biomedical Research Centre and chair of the British Association for Paediatric Nephrology and UK Renal Registry Audit and Informatics committee having previously been the chair of the National Health Service Blood and Transplant Paediatric Kidney Advisory Group.

His research continues to date in the fields of renal transplantation (including innovative drug trials concerning new anti-rejection therapies and assessment of children post-renal transplantation), systemic lupus erythematosus and vasculitis. He is on the editorial board for British Journal of Renal Medicine and is associate editor for Transplantation, “Pediatric Nephrology” and “Pediatric Transplantation”, which are the journals of The Transplantation Society, the International Pediatric Nephrology Association and the International Pediatric Transplant Association (IPTA) respectively. Having been chair of the Publications and Communications Committee, he is now a Councillor of IPTA.

"I love seeing how we are able to improve the quality of life for our patients on dialysis after they receive a good functioning kidney transplant. I love looking after the patients for many years and seeing them throughout their childhood and growing up into young adults! I love working with members of our team as we all aim to improve the long term outcomes of our patients."

Professor Stephen Marks

Specialisms

  • renal transplantation
  • systemic lupus erythematosus
  • vasculitis
  • glomerular diseases

Qualifications

  • MBChB (Glasgow) 10 July 1993
  • MRCP (UK) 25 March 1996
  • DCH (London) 16 April 1996
  • MRCPCH 1 March 1998.
  • MSc in Clinical Paediatrics (UCL) 1 November 2000 (Four distinctions)
  • FRCPCH 1 March 2005
  • MD (University of London) 31 May 2008

Memberships of the following paediatric (and adult) nephrology and transplantation groups including:

  • UK Kidney Association
  • British Transplantation Society
  • Royal College of Paediatrics and Child Health;
  • British Association for Paediatric Nephrology
  • European Society for Paediatric Nephrology
  • European Society of Organ Transplantation
  • International Pediatric Nephrology Association
  • International Pediatric Transplant Association
  • International Pediatric Hypertension Association
  • International Society of Nephrology
  • General Medical Council
  • British Medical Association
  • Medical Defence Union

Research Interests

Professor Stephen Marks' research continues to date in the fields of renal transplantation, including collaborative research of urine, blood and MRI biomarker studies, innovative drug trials concerning new anti-rejection therapies and assessment of children post-renal transplantation, examining the fine balance between rejection and infection with biomarkers of paediatric renal transplantation (and avoidance of EBV-driven post-transplant lymphoproliferative disorder). His academic work continues into the areas of autoimmunity and glomerular diseases, including juvenile onset systemic lupus erythematosus (SLE) and vasculitis where he is researching the aetiopathogenesis, management and outcome of childhood onset SLE, lupus nephritis and vasculitis. There are currently several projects looking at clinicopathological correlations and treatment of SLE and vasculitis with novel agents.

Publications

  1. Mudalige NL, Brown C, Marks SD. “The impact of donor and recipient sex on kidney allograft survival in pediatric transplant recipients.”Pediatr Nephrol 2022; 37(1): 209 -216.
  2. Rangoonwala S, Marks SD. “Kidney transplantation outcomes for children and young people with lupus nephritis.” Pediatr Transplant 2022; 26(1): e14193.
  3. Preka E, Sekar T, Lopez Garcia SC, Shaw O, Kessaris N, Mamode N, Stojanovic J, Sebire NJ, Kim JJ, Marks SD. “Outcomes of paediatric kidney transplant recipients using the updated 2013/2017 Banff histopathological classification for antibody-mediated rejection.” Pediatr Nephrol 2021; 36(8): 2575 - 2585.
  4. Sinha R, Agrawal N, Xue Y, Chanchlani R, Pradhan S, Raina R, Marks SD. “Use of rituximab in paediatric nephrology.” Arch Dis Child 2021; 106(11): 1058 - 1065.
  5. Marlais M, Martin K, Marks SD. “Improved renal allograft survival for pre-emptive paediatric renal transplant recipients in the United Kingdom.” Arch Dis Child 2021; 106(21): 1191 - 1194.
  6. Kim JS, Marlais M, Balasubramanian R, Muorah M, Inward C, Smith GC, Reynolds BC, Yadav P, Morgan H, Shenoy M, Tse Y, Hussain F, Grylls S, Kessaris N, Sinha MD, British Association for Paediatric Nephrology, Marks SD. “UK national study of barriers to renal transplantation in children.” Arch Dis Child 2021; 106(4): 384 - 386.
  7. Plumb L, Casula A, Pyart R, Evans KM, Inward C, Medcalf J, Marks SD. “The 21st UK Renal Registry Annual Report: a summary of analyses of paediatric data in 2017.” Nephron 2020; 144(2): 67 - 71.
  8. Preka E, Ellershaw D, Chandler N, Ahlfors H, Spencer H, Chitty L, Fenton MJ, Marks SD. "Cell free DNA in paediatric solid organ transplantation using a new detection method of separating donor-derived from recipient cell free DNA." Clin Chem 2020; 66(10): 1300 - 1309.