Sachin Khambadkone

Dr Sachin Khambadkone is a Consultant in Paediatric Cardiology, an Interventional Cardiologist and the Clinical Lead for Transition. He is Chief of Cardiology and he has worked at Great Ormond Street Hospital since 1997.

He is one of the three Interventional Cardiologist and was one of the Grant Holders and team leaders for introducing percutaneous pulmonary valve implantation, a novel technique of performing valve replacement without open heart surgery. This remains a landmark technique that has expanded to use of valve repair and replacement procedures in children and adults alike.


Dr Khambadkone has extensive training in general paediatrics, neonatology and paediatric cardiology. With his clinical experience of over 25 years, he is an expert in diagnosing and treating all aspects of cardiac problems ranging from heart murmurs, chest pain or heart failure related to structural heart disease.

In Interventional Cardiology, Dr Khambadkone was part of the pioneering team that introduced heart valve replacement procedure for the pulmonary valve, without open heart surgery. He was one of the first Proctor or Trainer for this technique and has helped set up programmes in many centres in UK, Europe and Asia. In addition to all interventional procedures such as balloon angioplasty, device closures of holes in the heart and valve implantations, he takes a keen interest in introducing novel techniques and devices.

Dr Khambadkone has expertise in advanced imaging techniques such as 3 D transthoracic and transesophageal echocardiography, echocardiography guided Trans catheter interventions and intra-operative echocardiography. He has a keen interest in 3D modelling of congenital heart lesions and use of 3D models in planning interventional and surgical treatment of congenital heart disease and patient education.

He is the Clinical Lead for Transition in Cardiology and has set up a Transition Clinic for teenage patients at Great Ormond Street Hospital. He runs a weekly clinic where teenagers are seen with problems such as chest pain, palpitations, syncope or fainting. With his team on Nurse Specialists and colleagues from the Grown Up Congenital Heart unit at St Bart’s Heart Centre, they provide a comprehensive and holistic care to young persons with congenital heart disease and their families to prepare for transfer to adult care during a very challenging time. He has established protocols for long term follow-up of operated congenital heart lesions. Dr Khambadkone was instrumental in setting up a unique event for teenagers and adolescents with congenital heart disease called “Rhythmic Beats” that is now used as a pan-London event for young persons to aid their Transition process.


  • MBBS, Mumbai, 1987
  • DCH College of Physicians and Surgeons, Mumbai 1990
  • MD University of Bombay 1991
  • DNB Diplomate of National Board of Exams, New Delhi, India 1991
  • MRCP Royal College of Physicians and Surgeon, London 1996
  • CCST Paediatric Cardiology, Royal College of Physicians and Surgeon, London 2004

Dr Khambadkone completed his medical school training and post graduate training in Paediatrics and Neonatology in Mumbai, India. He has a large experience in treating acute rheumatic fever and rheumatic heart disease, which is a rare and complex condition. He then trained in neonatology at Queen Charlotte and Chelsea, and Hammersmith Hospitals acquiring skills in tertiary care units.

He trained in Paediatric Cardiology at Great Ormond Street Hospital and got his CCST (Certificate of completion of Specialist Training). During this period, he was a British Heart Foundation Research Fellow and conducted clinical research in Fontan circulation. He specialised in Interventional Cardiology during his final years of training.

Research Interests

  • Percutaneous pulmonary valve implantation
  • Trans catheter valve interventions
  • Fontan circulation
  • Interventional strategies in heart failure
  • 3 D modelling of congenital heart lesions for planning interventions
  • 3D echocardiography
  • Ebstein anomaly
  • Anomalous coronary artery origins