Alistair Calder

Alistair Calder

Dr Alistair Calder is a consultant paediatric radiologist; he has been working in the radiology department at Great Ormond Street Hospital since 2005.

"I love working in paediatric radiology; we get to see an enormous range of rare and interesting disorders, for which we often make a key contribution in establishing a correct diagnosis."


All aspects of general paediatric diagnostic radiology. Special interests include imaging of the heart and lungs, and diagnosis of inherited disorders of bone (skeletal dysplasias).


BA (Hons) Cantab, BM BCH Oxon, FRCR (UK)

Research Interests

Dr Calder contributes to the London Cystic Fibrosis Collaboration’s research on CT scanning compared with lung function in children with cystic fibrosis. He is a reviewing radiologist for the EU Children’s Interstitial Lung Disease research group (ChildEU).

He is radiology committee member of the UK Skeletal Dysplasia Group for teaching and research, and an active member of the International Skeletal Dysplasia Society.

Key recent publications

Le Quesne Stabej P, James C, Ocaka L, Tekman M, Grunewald S, Clement E, Stanescu HC, Kleta R, Morrogh D, Calder A, Williams HJ, Bitner-Glindzicz M. An example of the utility of genomic analysis for fast and accurate clinical diagnosis of complex rare phenotypes. Orphanet J Rare Dis. 2017 Feb 7;12(1):24.

Tadros S, Scott RH, Calder AD, Hurst JA. Metaphyseal dysplasia, Spahr type; missense MMP13 mutations in two Iraqi siblings. Clin Dysmorphol. 2017 Jan;26(1):13-17

Shelmerdine SC, Brittain H, Arthurs OJ, Calder AD. Achondroplasia: Really rhizomelic? Am J Med Genet A. 2016 Aug;170(8):2039-43

Tooley M, Lynch D, Bernier F, Parboosingh J, Bhoj E, Zackai E, Calder A, Itasaki N, Wakeling E, Scott R, Lees M, Clayton-Smith J, Blyth M, Morton J,Shears D, Kini U, Homfray T, Clarke A, Barnicoat A, Wallis C, Hewitson R, Offiah A, Saunders M, Langton-Hewer S, Hilliard T, Davis P, Smithson S. Cerebro-costo-mandibular syndrome: Clinical, radiological, and genetic findings. Am J Med Genet A. 2016 May;170A(5):1115-26

Merrick B, Calder A, Wakeling E. Dysspondyloenchondromatosis (DSC) associated with COL2A1 mutation: Clinical and radiological overlap with spondyloepimetaphyseal dysplasia-Strudwick type (SEMD-S). Am J Med Genet A. 2015 Dec;167(12):3103-7.

Calder AD. Radiology of Osteogenesis Imperfecta, Rickets and Other Bony Fragility States. Endocr Dev. 2015;28:56-71.

Watson SG, Calder AD, Offiah AC, Negus S. A review of imaging protocols for suspected skeletal dysplasia and a proposal for standardisation. Pediatr Radiol. 2015 Nov;45(12):1733-7.

Giudici V, Kanani M, Muthialu N, Carr M, Calder AD, Owens CM, Cook AC, Marek J. Duplicated left pulmonary artery: an unknown disease? Three case reports and review of the literature. Cardiol Young. 2016 Feb;26(2):340-6.

Calder AD, Offiah AC. Foetal radiography for suspected skeletal dysplasia: technique, normal appearances, diagnostic approach. Pediatr Radiol. 2015 Apr;45(4):536-48.

Calder AD, Bush A, Brody AS, Owens CM. Scoring of chest CT in children with cystic fibrosis: state of the art. Pediatr Radiol. 2014 Dec;44(12):1496-506.

Goodwin SJ, Randle E, Iguchi A, Brown K, Hoskote A, Calder AD. Chest computed tomography in children undergoing extra-corporeal membrane oxygenation: a 9-year single-centre experience. Pediatr Radiol. 2014 Jun;44(6):750-60;

Scott RH, Meaney C, Jenkins L, Calder A, Hurst JA. The postnatal features of bent bone dysplasia-FGFR2 type. Clin Dysmorphol. 2014 Jan;23(1):8-11.

Parry DA, Logan CV, Stegmann AP, Abdelhamed ZA, Calder A, Khan S, Bonthron DT, Clowes V, Sheridan E, Ghali N, Chudley AE, Dobbie A, Stumpel CT, Johnson CA. SAMS, a syndrome of short stature, auditory-canal atresia, mandibular hypoplasia,and skeletal abnormalities is a unique neurocristopathy caused by mutations in Goosecoid. Am J Hum Genet. 2013 Dec 5;93(6):1135-42.

Sousa SB, Jenkins D, Chanudet E, Tasseva G, Ishida M, Anderson G, Docker J, Ryten M, Sa J, Saraiva JM, Barnicoat A, Scott R, Calder A, Wattanasirichaigoon D,Chrzanowska K, Simandlová M, Van Maldergem L, Stanier P, Beales PL, Vance JE, Moore GE. Gain-of-function mutations in the phosphatidylserine synthase 1 (PTDSS1) gene cause Lenz-Majewski syndrome. Nat Genet. 2014 Jan;46(1):70-6.

Thia LP/Calder A, Stocks J, Bush A, Owens CM, Wallis C, Young C, Sullivan Y,Wade A, McEwan A, Brody AS; London Cystic Fibrosis Collaboration. Is chest CT useful in newborn screened infants with cystic fibrosis at 1 year of age? Thorax.2014 Apr;69(4):320-7.


Radiology Department, Great Ormond Street Hospital.