Blinatumomab is used to treat various types of leukaemia (cancer of the white blood cells). Blinatumomab is a ‘biologic’ medicine, that is, it is a manmade version of a naturally occurring antibody. It works by stopping the particular type of leukaemia cells from growing. This page from Great Ormond Street Hospital (GOSH) explains what blinatumomab is, how it is given and some of the possible side

Blinatumomab is given as an infusion into a vein (intravenously or IV), through a central venous catheter or implantable port. It is usually given continuously (24 hours a day) for four weeks followed by a two week break without the infusion. It may be given at home using a portable infusion pump.

Antihistamine medicines to stop an allergic reaction are given one hour before the infusion is started. Corticosteroid medicine and paracetamol may also be given at this point.

Effects on the unborn child

Blinatumomab must not be given to girls who may be pregnant or are likely to become pregnant in the near future. If your daughter is ten years old or older, we will ask her about her periods and any possibility that she could be pregnant. We will also carry out a pregnancy test on a fresh urine sample. If your daughter is sexually active, she must use a reliable form of contraception.

What are the side effects?

Allergic reaction

Some people receiving blinatumomab have an allergic reaction to the medicine. This reaction may be mild to severe.

Signs of a mild allergic reaction include skin rashes and itching, high temperature, shivering, redness of the face, a feeling of dizziness or headache. If you see any of these signs, please report them to a doctor or nurse.

Signs of a severe allergic reaction include any of the above, as well as shortness of breath. If you are in hospital and your child shows signs of a severe allergic reaction, call a doctor or nurse immediately.

Neurological effects

If your child develops shakes, confusion, difficulties in communicating and/or seizures, call a doctor or nurse immediately.

Altered blood counts

There will be a temporary reduction in how well your child’s bone marrow works. This means they may become anaemic (reduced blood cells), bruise or bleed more easily than usual, and have a higher risk of infection.

Your child’s blood counts will be checked regularly to see how the bone marrow is working. Please tell your doctor if your child seems unusually tired, has bruising, bleeding, or any signs of infection, especially a high temperature.

Altered levels of minerals in blood

While your child is having blinatumomab, the levels of potassium, uric acid and phosphate in the blood may increase and the amount of calcium go down. Your child’s blood counts will be checked regularly and supplements may be given if needed.

Increased risk of infection

Tell the doctor if your child has any signs of infection, such as a high temperature, sore throat, upset tummy or pain when weeing. In most cases, they are not serious but it is best to check.

Upset stomach, nausea and vomiting

Anti-sickness medicines can be given to reduce or prevent these symptoms. Please tell your doctor or nurse if your child’s sickness is very bad or lasts for more than a few days.

Skin rashes and blistering

This is rare but could be serious. If your child develops any redness to their skin or blisters and a raised temperature, tell your doctor immediately.

Interactions with other medicines

Some medicines can react with blinatumomab, altering how well it works. Always check with your doctor or pharmacist before giving your child any other medicine, including medicines on prescription from your family doctor (GP), medicines bought from a pharmacy (chemist) or any herbal or complementary medicines.


Alert card

We recommend that your child carries a biological therapy alert card at all times. This could be important if your child needs emergency treatment for any reason.

Chicken pox

If your child is on blinatumomab and has not had chickenpox but comes into contact with someone who has chicken pox or shingles (either face to face or longer than 15 minutes in the same room), you should report to your doctor immediately as your child may be at risk of developing a more severe form of the infection an may need special treatment. If your child gets chicken pox or shingles you should also report to your doctor immediately for antibiotics to be given. If you are unsure whether your child has had chicken pox prior to starting blinatumomab, their immunity should be checked with a simple blood test at that time and the result entered on the parent-held monitoring card.


Your doctor will advise you if your child should avoid immunisation during treatment. Your child should NOT have any live vaccinations such as MMR, oral polio, chicken pox or BCG while taking blinatumomab. Inactivated or killed vaccines such as influenza/flu, meningitis C, pneumococcal, hepatitis, Hib, tetanus, diphtheria, whooping cough/pertussis and the killed version of the polio immunisation are permitted if the patient is stable under treatment. If you have other children who need vaccines while your child is taking blinatumomab, they should have these as normal, but they should also receive the ‘killed’ or inactivated polio vaccine. If you have any questions about vaccines and immunisations, please ask your doctor.

Compiled by:
The Pharmacy team in collaboration with the Child and Family Information Group
Last review date:
October 2019