NK killing assay (research and development assay)


NK killing assay



Clinical indications

Low or absent natural killer (NK) cell activity is common prior to and during active disease, as well as after remission following chemotherapy in a significant proportion of individuals with Familial HLH. Only offered after discussion with Clinical Lead. Perforin, GRA (SAP/XIAP if male) should be used to screen patients suspected of primary HLH

Specimen requirement

10 mls lithium heparin plus a healthy control sample. Please send 1ml extra EDTA for DNA storage

Dispatch and handling instructions

This is a 2-day assay, please do not send on a Friday. Samples should be less than 24 hours old. R&D Assay. LSS should be requested to ensure the presence of NK cells before assay setup. This test should only be undertaken under the direction of a Consultant Immunologist/ Senior Clinical Scientist. External referrals must be discussed with Dr Kimberly Gilmour (020 7813 8466) or her deputy and accompanied by a completed referral form (available on website)

Turnaround time

5 days


Not applicable

Is it IS0 15189 accredited?

No (research)