Autoimmune profile


Autoantibody screen



Clinical indications

(NB: does not include ANA) - Detects the following antibodies:

1. Smooth muscle (SM): often a non-specific finding. Occurs in type I autoimmune hepatitis (along with ANA). Also found in some patients with Hepatitis A and C infections

2. Liver kidney microsomal (LKM): found in Type 2 autoimmune hepatitis. Also occurs in Hepatitis C

3. Mitochondrial (MITO): found in primary biliary cirrhosis (a rare disease in children) Gastric parietal cell (GPC): found in pernicious anaemia. This is very rare in children

Specimen requirement

0.5ml serum / serum gel. Serological assays may be affected by icteric/lipaemic/haemolysed samples. These should be avoided if possible

Dispatch and handling instructions

Sent to Royal London

Turnaround time

14 days


Not applicable

Is it IS0 15189 accredited?