Autoimmune profile

EPIC

Autoantibody screen

Section

Immunology

Clinical indications

(NB: does not include ANA) - Detects the following antibodies:

1. Smooth muscle (SM): often a non-specific finding. Occurs in type I autoimmune hepatitis (along with ANA). Also found in some patients with Hepatitis A and C infections

2. Liver kidney microsomal (LKM): found in Type 2 autoimmune hepatitis. Also occurs in Hepatitis C

3. Mitochondrial (MITO): found in primary biliary cirrhosis (a rare disease in children) Gastric parietal cell (GPC): found in pernicious anaemia. This is very rare in children

Specimen requirement

0.5ml serum / serum gel. Serological assays may be affected by icteric/lipaemic/haemolysed samples. These should be avoided if possible

Dispatch and handling instructions

Sent to Royal London

Turnaround time

14 days

Synonym

Not applicable

Is it IS0 15189 accredited?

Sent to referral laboratory