https://www.gosh.nhs.uk/wards-and-departments/departments/laboratory-medicine/laboratory-database/autoimmune-profile/
Autoimmune profile
EPIC
Autoantibody screen
Section
Immunology
Clinical indications
(NB: does not include ANA) - Detects the following antibodies:
1. Smooth muscle (SM): often a non-specific finding. Occurs in type I autoimmune hepatitis (along with ANA). Also found in some patients with Hepatitis A and C infections
2. Liver kidney microsomal (LKM): found in Type 2 autoimmune hepatitis. Also occurs in Hepatitis C
3. Mitochondrial (MITO): found in primary biliary cirrhosis (a rare disease in children) Gastric parietal cell (GPC): found in pernicious anaemia. This is very rare in children
Specimen requirement
0.5ml serum / serum gel. Serological assays may be affected by icteric/lipaemic/haemolysed samples. These should be avoided if possible
Dispatch and handling instructions
Sent to Royal London
Turnaround time
14 days
Synonym
Not applicable
Is it IS0 15189 accredited?
Sent to referral laboratory