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Factor XI deficiency

Factor XI deficiency (also known as Haemophilia C, plasma thromboplastin antecedent deficiency or Rosenthal syndrome) is a clotting disorder. A specific protein is missing from the blood so that injured blood vessels cannot heal in the usual way. This information sheet from Great Ormond Street Hospital (GOSH) explains the causes, symptoms and treatment of Factor XI deficiency and where to get help.

Lomustine

Lomustine is a chemotherapy medicine used to treat certain types of cancer. It is also sometimes known as CCNU. This page from Great Ormond Street Hospital (GOSH) explains what lomustine is, how it is given and some of the possible side effects. 

Keeping history alive: relocating the Italian Hospital's altar

Building is underway to transform the Grade II listed Italian Hospital building into the new Great Ormond Street Hospital (GOSH) Sight and Sound Centre, supported by Premier Inn. But what happens to a beautiful 100-year-old altar secluded within the old building’s chapel? We talk to Crispin Walking-Lea, Head of Healthcare Planning at GOSH.

Epidermolysis bullosa simplex: localised and generalised types

This page from Great Ormond Street Hospital (GOSH) explains about the localised and generalised forms of epidermolysis bullosa simplex and how they can be treated. It also contains suggestions for making everyday life more comfortable. The localised form was previously known as Weber Cockayne epidermolysis bullosa simplex and the generalised form Köbner epidermolysis bullosa simplex.

Generalised lymphatic anomaly (GLA)

Generalised lymphatic anomaly (GLA) – previously known as lymphangiomatosis – is the name given to a rare, congenital (present at birth), and progressive disorder of lymphatic channels which can affect different organs including the bones and the intestines. It can cause problems if the abnormal lymphatic tissue develops within important tissues and structures. This information sheet from Great Ormond Street Hospital (GOSH) explains the causes, symptoms and treatment of generalised lymphatic anomalies (GLA) and where to get help. 

Assessment for craniofacial surgery

You may already have seen members of the craniofacial team but often we ask for a more detailed assessment to plan treatment now and in the future. This craniofacial assessment takes place over two to three days and involves other members of the multidisciplinary craniofacial team. This page from Great Ormond Street Hospital (GOSH) explains the series of appointments that make up the craniofacial assessment process. 

Embolisation

Embolisation is a way of blocking abnormal blood vessels. This page from Great Ormond Street Hospital (GOSH) explains about embolisation, why it might be suggested and what to expect when your child comes to GOSH for treatment. 

Oesophageal atresia with tracheo-oesophageal fistula

Oesophageal atresia (OA) is a rare condition where a short section at the top of the oesophagus (gullet or foodpipe) has not formed properly so is not connected to the stomach. This means food cannot pass from the throat to the stomach. Tracheo-oesophageal fistula (TOF) is another rare condition, which tends to occur alongside oesophageal atresia. This is where part of the oesophagus is joined to the trachea (windpipe). This page explains about oesophageal atresia and tracheooesophageal fistula, how they are treated and what to expect when your child comes to Great Ormond Street Hospital (GOSH) for treatment.

Functional symptoms

Functional symptoms are physical symptoms without an obvious cause. They can also be called Medically Unexplained Symptoms, Somatic Symptom Disorder, Somatoform Disorder or Functional Neurological Disorder. This page from Great Ormond Street Hospital (GOSH) explains about functional symptoms in children and young people and how they can be managed.