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Trametinib

Trametinib is used to treat various types of cancer. It is a ‘biologic’ medicine, that is, it works by stopping the process that makes cancer cells grow and divide.This page from Great Ormond Street Hospital (GOSH) explains what trametinib is, how it is given and some of the possible side effects. 

Multiple sclerosis and fatigue

Fatigue is an overwhelming sense of tiredness and exhaustion, and is a very common symptom in MS, with most people with MS experiencing fatigue in some way at some time. This information sheet from Great Ormond Street Hospital (GOSH) explains about
the fatigue that is a common feature of multiple sclerosis (MS). As well as describing what we know about fatigue, it also gives some suggestions to manage it.

Biopsy

A biopsy is a small sample of tissue taken from the body so it can be examined under a microscope and tested chemically in the laboratories. This page from Great Ormond Street Hospital (GOSH) explains about the procedure to take a biopsy in the Interventional Radiology department. 

Your child is having an echocardiogram under sedation

Echocardiograms (Echo) are one of the most frequently used scans for diagnosing heart problems. An Echo is an ultrasound scan of the heart. As your child will need to lie very still for the scan, we may suggest that they have sedation to help. This information sheet from Great Ormond Street Hospital (GOSH) explains about echocardiograms, what is involved and what to expect when your child has the scan.

Landau Kleffner Syndrome: language and communication

Children with Landau Kleffner Syndrome (LKS) experience a significant regression in their understanding and use of spoken language. This loss of skills often occurs at the onset of the disease and can be the first sign for families that something is wrong. This information sheet from Great Ormond Street Hospital (GOSH) describes how Landau Kleffner Syndrome (LKS) can affect a child’s language skills and outlines recommendations for input and support.

Oesophageal manometry

Manometry is a way of measuring how well the muscles and nerves in the digestive system are working. Oesophageal manometry looks at the muscles and nerves in the oesophagus (foodpipe). This page from Great Ormond Street Hospital (GOSH) explains about the oesophageal manometry test and what to expect when your child has one. 

Neuropathic pain medicines

This page from Great Ormond Street Hospital (GOSH) explains about medicines used to treat neuropathic pain – pain caused by the nerves sending wrong signals to and from the brain. At GOSH, we mainly use amitriptyline, gabapentin and pregabalin, although other medicines are available.

Brugada syndrome

Brugada syndrome is an inherited condition caused by a change in a person’s DNA. People with Brugada syndrome have changes in the microscopic structure of individual heart muscle cells – these changes affect the way that electrical impulses are able to pass through the heart. This information sheet from Great Ormond Street Hospital (GOSH) explains about the medical condition Brugada syndrome, what causes it and where to get help.

Helping young children cope with hospital

Hospitals can be strange places for young children. On a visit to hospital, they will encounter lots of different people in an unfamiliar environment. There will be many new things to see, hear and smell and there may be lots of waiting. Along with the general disruption this brings to the normal routine, all these things can make hospital visits stressful or overwhelming for young children and their families.

This page from Great Ormond Street Hospital (GOSH) aims to give you some reassurance and a few ideas for how you could approach them. All these suggestions come from our play team, who between them have many years of experience working with children, young people and families in hospital. If you have any particular tips or methods that have worked for you, please contact us to tell us about them.

Helping your child get used to their hearing aid or cochlear implant

It can be challenging for some parents and carers of deaf and hearing-impaired children and young people, especially those with additional and complex needs, to get them to accept their hearing devices. This includes behind-the-ear hearing aids, bone anchored hearing aids and cochlear implants.

This is often due to sensory sensitivity – that is not liking the feeling of having anything on their head such as a hat or hair clip, or wanting anything touching their head and hair, for instance, brushing or washing. This sensitivity can affect how they cope with hearing devices so they become anxious and even ‘fearful’ of them.

This information sheet from the Audiology team at Great Ormond Street Hospital (GOSH) explains how you can help your child to manage sensory sensitivity so wearing hearing devices becomes easier with time.

Imatinib

Imatinib is a chemotherapy medicine used to treat certain types of cancer. This page from Great Ormond Street Hospital (GOSH) explains what imatinib is, how it is given and some of the possible side effects. 

Treating and reducing the risk of pressure ulcers after leaving hospital

Our skin is the most important barrier against infection so we need to look after it carefully. Sometimes, for a variety of reasons, people who are unwell develop pressure ulcers. At Great Ormond Street Hospital (GOSH), we recognise that children can develop pressure ulcers too. This information sheet explains about the steps you can continue to take at home to reduce the risk of your child developing a pressure ulcer. It also explains how to manage a pre-existing pressure ulcer at home.

Isotretinoin

Isotretinoin is a retinoid, which is a type of Vitamin A. It is commonly used for the treatment of severe acne. Retinoids are thought to influence the way in which cells grow and develop, and prevent the production of specific genes that may cause cancer.This page from Great Ormond Street Hospital (GOSH) explains what isotretinoin is, how it is given and some of the possible side effects. 

Cleft lip repair

Cleft lip repair is an operation to reconstruct the shape of the lip and nose. If there is a cleft palate as well, then the front half (anterior) of the palate is also repaired. This information sheet explains about the operation to repair a cleft lip and what to expect when your child comes to the North Thames Cleft Service for the operation.

Factor XIII deficiency

Factor XIII deficiency is a type of clotting disorder. A specific protein is missing from the blood so that injured blood vessels cannot heal in the usual way. This information sheet from Great Ormond Street Hospital (GOSH) explains the causes, symptoms and treatment of Factor XIII deficiency and where to get help.