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Headaches affect people of all ages – many adults remember having headaches as children. Headache in children can occur on its own (primary disorder) or as a result of another condition.

Paul O'Grady's Little Heroes: Episode five

Paul meets brothers Freddie (4) and Arthur (2), who are both being treated at Great Ormond Street Hospital (GOSH) for unrelated cancers – Arthur was diagnosed with a brain tumour and three months later, Freddie was diagnosed with sarcoma, a soft tissue cancer.

Paul also catches up with George (15), was born with two small holes in his heart and a thickness in his heart muscles. George’s condition is very rare in children, with only a few hundred people in the UK developing the condition in childhood.

Finally, we meet Angel (4), who was just three months old when doctors in Peterborough discovered she had tumours in both her kidneys. When chemotherapy was unsuccessful, she had to have both kidneys removed at GOSH and is now waiting for a transplant.