Our long-term commitment to instigating, supporting and delivering cutting-edge research means there are a wide variety of research projects under way at Great Ormond Street Hospital (GOSH) at any given time.
Every year around two hundred research projects are started, while at any one time there are roughly five hundred research projects active at the Trust.
All research taking place at GOSH is structured around our six clinical areas:
- Critical Care and Cardio-Respiratory
- Diagnostic and Therapeutic Services
- Infection, Cancer and Immunity
This work is strengthened by collaborative research conducted with teams from the five academic programmes of the UCL Great Ormond Street Institute of Child Health (ICH):
- Developmental Biology and Cancer
- Developmental Neurosciences
- Genetics and Genomic Medicine
- Infection, Immunity, Inflammation and Physiological Medicine
- Population, Policy and Practice
Academics at ICH and clinicians at GOSH work together to continue our integrated and multi-disciplinary approach to the understanding, diagnosis, treatment and prevention of childhood disease. Since many staff hold appointments at both institutions, GOSH and ICH researchers are able to translate research undertaken in laboratories into actual trials in the hospital. We can ensure research offers a real benefit to the children at GOSH, elsewhere in the NHS and internationally.
Clinical trial performance
As part of the National Institute for Health Research (NIHR)'s aim for faster, easier clinical research, all NHS organisations in receipt of NIHR funding are required to report their performance against two metrics on a quarterly basis:
Performance in Initiation: studies where GOSH has been selected as a site in the past 12 months. As of 18/19 Q1, this will no longer be assessed with a 70 day benchmark. Instead, the focus is placed on transparency, accuracy, and meeting expectations.
Performance in Delivering: the number of commercial contract clinical trials that recruit their agreed number of participants within the agreed time frame.
Further information on why this is measured, and the NIHR’s official guidance and requirements, can be found on the NIHR website.
We submit quarterly reports to the NIHR setting out our performance against these metrics. This data is also available below and will be updated quarterly.
For clinical trials where GOSH was selected as a site between 1 January 2018 and 31 December 2018. Once we have been selected, we aim to confirm the trial within 40 days and recruit a patient within 30 days of confirming as a site. If the benchmarks were not met, for any reason(s), then we have provided information as to how this occurred.
For commercial contract clinical trials that closed to recruitment between 1 January 2018 and 31 December 2018. Commercial contract clinical trials will often have a contractually agreed target number of participants, and a date agreed to recruit all these participants. Once the trial closes to recruitment, we report whether we've met these targets.