https://www.gosh.nhs.uk/our-research/our-research-infrastructure/nihr-great-ormond-street-hospital-brc/brc-news/funding-provided-develop-new-therapy-acute-liver-failure/
Funding provided to develop new therapy for acute liver failure
9 Sep 2015, 4:50 p.m.
BRC-supported researcher Dr Kevin Mills has been awarded funding from the NIHR to investigate the regenerative ability of the liver following acute liver failure (ALF). If successful, the team hope that their research will lead to a novel therapy that could buy patients enough time to allow their livers to regenerate naturally, avoiding the need for liver transplantsThis research will be led by Professor Anil Dhawan at Kings College London in collaboration with Dr Mills at UCL Institute of Child Health. Specifically, the team aim to develop a novel technique where human liver cells grown in the lab are encapsulated in a material called alginate and delivered to a patient to help their ailing liver regenerate. Encasing the liver cells in alginate is particularly important as it reduces the need for immunosuppression.
Studies in the lab will focus on the feasibility of this novel therapy under lab conditions.
Building the next generation of paediatric research leaders
From early career clinicians to emerging scientists, the NIHR GOSH Biomedical Research Centre (BRC)’s Academic Training Weekend is shaping the future of paediatric research - bringing together talent, expertise and ambition from across the UK.
Bagri family philanthropy enables UCL study into rare childhood neurological condition treated at GOSH
A generous donation from the Bagri family will underpin a landmark study into gene-editing treatments for Dihydropteridine reductase deficiency (DHPR deficiency), an ultra-rare childhood neurological condition, treated at GOSH
Creating communities and lasting involvement
At GOSH, patient and public involvement and engagement (PPIE) builds lasting relationships and communities that shape research over time.
Junior researchers are crucial to the future of paediatric research
Junior researchers are central to the success and sustainability of paediatric research at GOSH and the University College London Institute of Child Health.