Neuronal migration disorder is an umbrella term given to several conditions including lissencephaly, agenesis of the corpus callosum and microgyria. They all arise while the baby is developing in the womb.This information sheet from Great Ormond Street Hospital (GOSH) explains the causes, symptoms and treatment of neuronal migration disorders and where to get help.
Periventricular leukomalacia (PVL) is a type of brain injury that is most common in babies born too soon (premature) or at low birthweight. The white matter (leuko) surrounding the ventricles of the brain (periventricular) is deprived of blood and oxygen leading to softening (malacia). The white matter is responsible for transmitting messages from nerve cells in the brain so damage to the white matter can cause problems with movement and other body functions.
Kasabach-Merritt phenomenon (KMP) refers to clotting problems arising as a result of the rare benign (non-cancerous) vascular lesions known as kaposiform haemangioendothelioma (KHE) and tufted angioma.Infantile haemangiomas never lead to KMP. This information sheet provides information about Kasabach-Merritt syndrome, what causes it and how it can be treated. It also explains what to expect when a child comes to Great Ormond Street Hospital (GOSH) for diagnosis and treatment.
Cystic fibrosis related diabetes (CFRD) is different to other types of diabetes. CFRD is caused by the build up of thick secretions in the pancreas. These secretions damage the cells that produce a hormone called insulin.
New onset diabetes after transplant (NODAT) affects between three and 13 per cent of children and young people who have an organ transplant. The medicines needed to prevent the body rejecting the organ also affect insulin production and uptake.
Steroids are hormonal chemical messengers that are produced naturally in the body by the adrenal glands (which are just above each kidney) and by the reproductive organs. Man-made versions of these hormonal substances are used to treat a wide range of illnesses and medical conditions.