Research and publications from the Tic Disorder Service

We have an ongoing programme of research, and you or your child may be invited to take part in a research project whilst under the care of the team.

This is always entirely voluntary, and whether you choose to participate or not, your clinical care will not be affected.

Any information gathered may be used anonymously for research purposes to improve our understanding and lead to better treatments for other children and families in the future.

Tourette syndrome
The team are interested in many aspects of understanding Tourette syndrome including the genetic factors as well as clinical interventions that benefit children and families.

  • Andrén P, Jakubovski E, Murphy TL, Woitecki K, Tarnok Z, Zimmerman-Brenner S, van de Griendt J, Debes NM, Viefhaus P, Robinson S, Roessner V, Ganos C, Szejko N, Müller-Vahl KR, Cath D, Hartmann A, Verdellen C. European clinical guidelines for Tourette syndrome and other tic disorders-version 2.0. Part II: psychological interventions. Eur Child Adolesc Psychiatry. 2022 Mar;31(3):403-423. doi: 10.1007/s00787-021-01845-z. Epub 2021 Jul 27. PMID: 34313861; PMCID: PMC8314030.
  • Buts, S., Duncan, M., Owen, T., Martino, D., Pringsheim, T., Byrne, S., McWilliams, A., Murphy, T., Malik, O., Liang, H., Heyman, I., & Hedderly, T. Paediatric tic-like presentations during the COVID-19 pandemic. Archives of Disease in Childhood. 2022.
  • Reilly C, Grant M, Bennett S, Murphy T, Heyman I. Review: Physical exercise in Tourette syndrome - a systematic review. Child Adolesc Ment Health. 2019 Feb;24(1):3-11. doi: 10.1111/camh.12263. Epub 2018 Feb 28. PMID: 32677234.
  • Andrén P, de la Cruz LF, Isomura K, Lenhard F, Hall CL, Davies EB, Murphy T, Hollis C, Sampaio F, Feldman I, Bottai M, Serlachius E, Andersson E, Mataix-Cols D. Efficacy and cost-effectiveness of therapist-guided internet-delivered behaviour therapy for children and adolescents with Tourette syndrome: study protocol for a single-blind randomised controlled trial. Trials. 2021 Sep 30;22(1):669. doi: 10.1186/s13063-021-05592-z. PMID: 34593015; PMCID: PMC8481317.
  • Dabrowski J, King J, Edwards K, Yates R, Heyman I, Zimmerman-Brenner S, Murphy T. The Long-Term Effects of Group-Based Psychological Interventions for Children With Tourette Syndrome: A Randomized Controlled Trial. Behav Ther. 2018 May;49(3):331-343. doi: 10.1016/j.beth.2017.10.005. Epub 2017 Dec 6. PMID: 29704964.
  • Cutler, D., Murphy, T., Gilmore, J., & Heyman, I. (2009). Quality of  life in young people with Gilles de la Tourette syndrome. Child care health development, 35(4), 496–502.
  • Murphy, T., & Muter, V. (2012). Risk factors for co-morbidity in ADHD and TS: looking beyond a single deficit model. Applied neuropsychology: Child. doi: Aug 3 10.1080/21622965.2012.703889
  • Su, M. T., McFarlane, F., Cavanna, A. E., Termine, C., Murray, I., Heidemeyer, L., ... & Murphy, T. (2017). The English Version of the Gilles de la Tourette Syndrome–Quality of Life Scale for Children and Adolescents (C&A-GTS-QOL) A Validation Study in the United Kingdom. Journal of Child Neurology, 32(1), 76-83.
  • Tourettes Is Not A Swear Word - Great Ormond Street Hospital Charity article.
  • Article on CBBC documentary featuring the specialist work of Great Ormond Street Hospital’s Tourette syndrome clinic.
  • JAMA Patient Page - Tics and Tourette Syndrome.

Genetics, Interventions, Medically Unexplained Symptoms, Epilepsy, Neurology and neurovascular Disorders, OCD, Multiple Sclerosis

  • Abdulkadir, A., Tischfield, A.J., King, R.A., Fernandez, T.V., Brown, L.W., … & Dietrich, A. (2016). Pre- and perinatal complications in relation to Tourette syndrome and co-occurring obsessive-compulsive disorder and attention-deficit/hyperactivity disorder. Journal of Psychiatric research, 82, 126-135.
  • Dietrich, A., Fernandez, T.V., King, R.A., State, M.W., Tischfield, J.A., …& Zinner, S.H. (2015). The Tourette International Collaborative Genetics (TIC Genetics) study, finding the genes causing Tourette syndrome: objectives and methods. Eur Child Adolesc Psychiatry, 24(2), 141-51.
  • Dietrich, A., Fernandez, T. V., King, R. A., Tischfield, J. A., Hoekstra, P. J., & Heiman, G. A. (2015). The Tourette International Collaborative Genetics (TIC Genetics) study, finding the genes causing Tourette syndrome: objectives and methods. European child & adolescent psychiatry, 24(2), 141-151.
  • Bennett, S., Heyman, I., Coughtrey, A., Simmonds, J., Varadkar, S., …& Shafran, R. (2016). Guided self-help interventions for mental health disorders in children with neurological conditions: study protocol for a pilot randomised controlled trial. Trials, 17(1), 532.
  • Bennett, S., Stark, D., Shafran, R., Heyman, I., & Krebs, G. (2015). Evaluation of cognitive behaviour therapy for paediatric obsessive-compulsive disorder in the context of tic disorders. J Behav Ther Exp Psychiatry, 49, 223-229.
  • Cuenca, J., Glazebrook, C., Kendall, T., Hedderly, T., Heyman, I., Jackson, G., ... & Trayner, P. (2015). Perceptions of treatment for tics among young people with Tourette syndrome and their parents: a mixed methods study. BMC psychiatry, 15(1), 46.
  • Hartmann, A., Martino, D., & Murphy, T. (2016). Gilles de la Tourette syndrome – A treatable condition? Revue Neurologique
  • Hollis, C., Pennant, M., Cuenca, J., Glazebrook, C., Kendall, T., …& Stern J. (2016). Clinical effectiveness and patient perspectives of different treatment strategies for tics in children and adolescents with Tourette syndrome: a systematic review and qualitative analysis. Health Technol Assess, 20(4), 1-450. 
  • Murphy, T. and Heyman, I. Group work in Young People with Tourette syndrome. (2007). Child and adolescent mental health, 12(1), 46-48.
  • Nussey, C., Pistrang, N., & Murphy, T. (2014). Does it help to talk about tics? An evaluation of a classroom presentation about Tourette syndrome. Child and Adolescent Mental Health, 19 (1), 31-38.
  • Nussey, C., Pistrang, N., & Murphy, T. (2013). How does psychoeducation help? A review of the effects of providing information about Tourette syndrome and attention‐deficit/hyperactivity disorder. Child: care, health and development, 39(5), 617-627.
  • Smith, H., Fox, J. R., Hedderly, T., Murphy, T., & Trayner, P. (2016). Investigating young people’s experiences of successful or helpful psychological interventions for tic disorders: An Interpretative Phenomenological Analysis study. Journal of health psychology, 21(8), 1787-1798.
  • Verdellen, C., Van De Griendt, J., Hartmann, A., Murphy, T., & ESSTS Guidelines Group. (2011). European clinical guidelines for Tourette syndrome and other tic disorders. Part III: behavioural and psychosocial interventions. European child & adolescent psychiatry, 20(4), 197-207.
  • Whittington, C., Pennant, M., Kendall, T., Glazebrook, C., Trayner, P., … & Hollis, C. (2016). Practitioner Review: Treatments for Tourette syndrome in children and young people – a systematic review. J Child Psychol Psychiatr, 57, 988–1004. 
  • Yates, R., Edwards, K , King, J., Luzon, O., Evangeli, M., … & Murphy,  T. (2016). Habit Reversal Training and Educational group treatments for children with Tourette Syndrome: a randomised controlled trial. Behavioral Research and Therapy, 80, 43–50.
  • Daniel, M. C., Coughtrey, A., Heyman, I., & Dahlmann-Noor, A. H. (2017). Medically unexplained visual loss in children and young people: an observational single site study of incidence and outcomes. Eye.
  • Reilly, C., McWilliams, A., & Heyman, I. (2015). What's in a name? 'Psychogenic' non-epileptic events in children and adolescents. Developmental Medicine and Child Neurology, 57 (1), 100-101. 
  • McWilliams, A., Reilly, C., McFarlane, F. A., Booker, E., & Heyman, I. (2016). Nonepileptic seizures in the pediatric population: A qualitative study of patient and family experiences. Epilepsy & Behavior, 59, 128-136.
  • Colonnelli, M. C., Cross, J. H., Davies, S., D’Argenzio, L., Scott, R.C., & Heyman I. (2012). Psychopathology in children before and after surgery for extra-temporal lobe epilepsy. Developmental Medicine & Child Neurology, 54, 521–526. Hannan, S., Cross, H., Harkness, W., & Heyman, I. (2009).  The effects of epilepsy surgery on emotions, behaviour and psychosocial impairment in children and adolescents with drug resistant epilepsy: a prospective study. Epilepsy and Behaviour, 15, 318-324.
  • McLellan, A., Davies, S., Heyman, I., Harding, B., Harkness, W., … & Cross, J.H. (2005). Psychopathology in children undergoing temporal lobe resection for the treatment of epilepsy – a pre and post-operative assessment. Dev Med and Child Neurol, 47, 666-672.
  • Bennett, S., Heyman, I., Coughtrey, A., Simmonds, J., Varadkar, S., Stephenson, T., ... & Shafran, R. (2016). Guided self-help interventions for mental health disorders in children with neurological conditions: study protocol for a pilot randomised controlled trial. Trials, 17(1), 532.
  • Gordon, A., Connelly, A., Neville, B., Vargha‐Khadem, F., Jessop, N., Murphy, T., & Ganesan, V. (2007). Modified constraint‐induced movement therapy after childhood stroke. Developmental Medicine & Child Neurology, 49(1), 23-27.
  • O’Keeffe, F., Ganesan, V., King, J., & Murphy, T. (2012). Quality-of-life and psychosocial outcome following childhood arterial ischaemic stroke. Brain injury, 26(9), 1072-1083.
  • O’Keeffe, F., Liégeois, F., Eve, M., Ganesan, V., King, J., & Murphy, T. (2014). Neuropsychological and neurobehavioral outcome following childhood arterial ischemic stroke: attention deficits, emotional dysregulation, and executive dysfunction. Child Neuropsychology, 20(5), 557-582.
  • O’Keeffe, F., Stark, D., Ganesan, V.,  King, J., & Murphy, T. (2017) Psychosocial outcome and quality of life following childhood stroke - A systematic review. Developmental Neurorehabilitation.
  • Eve, M., O'Keeffe, F., Jhuti, S., Ganesan, V., Brown, G., & Murphy, T. (2016). Computerised working memory training for children following arterial ischemic stroke: A pilot study with long-term follow-up. Applied Neuropsychology: Child, 5(4), 273-282.
  • Barton, R., & Heyman, I. (2016). Obsessive–compulsive disorder in children and adolescents. Paediatrics and Child Health, 26(12), 527-533.
  • Heyman, I. (2014). Cognitive-behavioural therapy with post-session D-cycloserine augmentation for paediatric obsessive-compulsive disorder: pilot randomised controlled trial. The British Journal of Psychiatry, 204(1), 77-78.
  • Jassi, A.D., Kolvenbach, S., Heyman, I., Macleod, T., Rose, J., & Diamond,  H. (2015). Increasing knowledge about obsessive compulsive disorder and support for parents and schools: Evaluation of initiatives. Health Education Journal, 75(5), 600-609.
  • UCL Great Ormond Street Institute of Child Health - Psychological Medicine Research.
  • Carroll, S., Chalder, T., Hemingway, C., Heyman, I., & Moss-Morris, R. (2016). “It feels like wearing a giant sandbag.” Adolescent and parent perceptions of fatigue in paediatric multiple sclerosis. European Journal of Paediatric Neurology, 20(6), 938-945.
  • Carroll, S., Chalder, T., Hemingway, C., Heyman, I., & Moss‐Morris, R. (2016). Understanding fatigue in paediatric multiple sclerosis: a systematic review of clinical and psychosocial factors. Developmental Medicine & Child Neurology, 58(3), 229-239.
  • Mataix-Cols, D., de la Cruz, L. F., Monzani, B., Rosenfield, D., Andersson, E., Pérez-Vigil, A., ... & Farrell, L. J. (2017). D-Cycloserine Augmentation of Exposure-Based Cognitive Behavior Therapy for Anxiety, Obsessive-Compulsive, and Posttraumatic Stress Disorders: A Systematic Review and Meta-analysis of Individual Participant Data. Jama psychiatry.