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Administration of Non-Cytotoxic Medication via an Intracerebroventricular Reservoir

The purpose of this document is to provide guidance for the administration of non-cytotoxic injection or infusion via an Intracerebroventricular (ICV) reservoir at Great Ormond Street Hospital (GOSH). 

This guideline is to be used for the administration of cerliponase alfa/BMN190 and may need to be adapted for administration of other ICV medications. 

For intrathecal or ICV administration of cytotoxic drugs please see the clinical guideline; Intrathecal cytotoxic chemotherapy: administration via a lumbar puncture or Ommaya reservoir.

Opsoclonus myoclonus syndrome / dancing eye syndrome (OMS/DES)

Opsoclonus myoclonus syndrome (OMS), also known as dancing eye syndrome (DES) or Kinsbourne syndrome, is a rare neurological condition which develops over days or weeks in early childhood. This information sheet from Great Ormond Street Hospital (GOSH) explains the causes, symptoms and treatment of opsoclonus myoclonus syndrome and where to get help.