Genomics and Systems Medicine - Single Cell Project Call

Nurse putting sample in PCR

CLOSED: This new call from The GOSH Biomedical Research Centre’s (BRC) Genomics and Systems Medicine theme is for projects that use single cell approaches to advance the characterization, diagnosis and treatment of childhood rare diseases.

Internal GOSH and ICH applicants only

The GOSH Biomedical Research Centre’s (BRC) Genomics and Systems Medicine theme has launched an exciting new call for projects that use single cell approaches and are aimed at advancing the characterization, diagnosis and treatment of childhood rare diseases.

DNA, RNA and protein readouts from single cells can be useful as biomarkers of disease onset and progression. With the ability to read thousands of individual cells, molecular changes in tissues can be discriminated across cell types and used to assess cell disease states. This is key to the mechanistic understanding of rare diseases and the subsequent translation of advances in their diagnosis and treatment.

Through this call, the BRC will support up to 3 projects using single cell approaches aimed at advancing the characterization, diagnosis and treatment of childhood rare diseases. Projects including patient samples or in vitro (iPSC and organoid) cell cultures will be prioritised, though projects involving in vivo models of rare disease may be considered where the project demonstrates a strong human translational research element and the in vivo single cell analysis is key for translation. Up to £25,000 in consumables support is available for each project and support for experimental design and analysis will also be made available. No animal work can be supported through this call.

Projects with diseased and control samples or models already available will be favoured in this call. Funds awarded must be spent by 28th February 2021 but experimental work and analysis of the resulting data may be continued after this date. The BRC welcomes proposals from Senior and Early career researchers and you do not need to have had any prior links with the BRC to be eligible to apply; applications are welcome from individuals who are new to the BRC.

Further details about the call and instructions on how to apply can be found in the Guidance Notes and Application Form (191.07 KB).The deadline for applications is Thursday 1st October 2020.