BRC New Projects Funding Call 2018/19

CLOSED: This funding call aims to fund a number of projects, primarily aimed at less well established researchers, and has a total of £125,000 available with a maximum of £25,000 per award, to be spent in UCL or GOSH. The call is for non-pay only, no salaries will be covered.

Internal GOSH and ICH applicants only

Why is it important?

The GOSH BRC funds translational, experimental medicine research. We aim to accelerate translation of basic science discoveries into the basis of childhood rare diseases into clinical research; developing new diagnostics, imaging techniques and treatments, including ‘first in child’ studies, with the ultimate aim of realising patient and economic benefits. This funding call aims to fund a number of projects, primarily aimed at less well established researchers. The project does not need to be within a disease area the BRC currently supports, but chosen projects will be placed within one of the four existing research themes - Gene, Stem and Cellular Therapies (GSCT), Genomics and Systems Medicine (GSM), Novel Therapies for Translation in Childhood Diseases (NT) & Advanced Treatments for Structural Malformation and Tissue Damage (ATSMTD).

Who can apply?

This funding call is open to all staff at GOSH/ICH, any grade but priority will be given to projects from less well established researchers, i.e. not currently Chief Investigators. These might be post-docs/clinical fellows/Nurses/AHPs (they should lead the application but written agreement to submit should be obtained from whoever pays their salary); Less established lecturers; or they could be more senior staff e.g. consultants who would like to get into research for the first time.

How much money is available?

The call has a total of £125,000 available with a maximum of £25,000 per award, to be spent in UCL or GOSH. The call is for non-pay only, no salaries will be covered. There is a maximum limit of £5000 on equipment purchases (including VAT). Applications with animal research will not be considered. All funds will need to be spent between 1 April 2019 and 31st March 2020, but the project timelines may go on longer than this, up to a maximum of 2 years.

Application process:

Applications open: 10 October 2018
Applications deadline: 07 December 2018
Award letters: Early January 2019
Funding available: 01 April 2019
Applicants must register their project with R&D and complete the application form, both can be found below. All applicants must update (if they have not done so) their cohorts catalogue data for their application to be considered. A copy of the cohorts catalogue will be sent to applicants to populate when they send their application. 
Contact details: Submit applications (with the subject line “BRC New Projects Call”) and queries to: and completed Project Registration forms to


In February 2019 we announced our first funding call and are pleased to announce the successful applicants. After careful consideration, the panel selected to fund the following projects:

Dr Alessia Cavazza

Targeted gene correction for Severe Combined Immunodeficiency caused by mutations in the IL7R gene.

Awarded - £16,000

Dr Claire Booth

Understanding SAP signalling mechanisms in XLP1 patient T cells to develop novel therapies.

Awarded - £23,125

Dr Claire Deakin

Dynamics of immune changes across age in healthy children and adolescents .

Awarded - £25,000

Dr Gavin Arno

Elucidating the Missing Heritability of Inherited Retinal Disease Genes.

Awarded - £22,400

Dr Giorgia Santilli

Gene editing for X-linked agammaglobulinemia.

Awarded - £13,327

Dr Lamia Boukhibar

RNAseq of Undiagnosed RaPS Patients.

Awarded - £24,850

Dr Louis Grandjean

RNA Metagenomic Sequencing of High Risk Placentas for the Diagnosis of Congenital Infection.

Awarded - £25,000

Dr Virginie Mariot

Therapeutic strategy for Myh7 induced cardiomyopathy.

Awarded - £21,182

Dr Patricia Hunter

Toward a molecular definition of bacterial vaginosis to improve diagnosis and treatment in high risk pregnancies for the prevention preterm birth.

Awarded - £14,020

Dr Sara Benedetti

Targeting the blood-brain barrier endothelium to increase hematopoietic stem cell engraftment for lysosomal storage disease gene and cell therapy.

Awarded - £21,000

Dr Serena Barral

Developing a three-dimensional human midbrain model to accelerate therapeutic approaches for childhood neurodegenerative diseases.

Awarded - £24,100

Dr William Dawes

Development of a human organotypic model of ciliated brain tissue to investigate the impact of intraventricular haemorrhage on brain development in the premature neonate.

Awarded - £25,000