Nikhil Thapar

Dr Thapar is the Academic Lead for Gastroenterology at Great Ormond Street Hospital.

Dr Thapar, with Drs Lindley and Borrelli, runs a specialist clinical service for children with congenital and acquired gut motility disorders, which includes state-of-the-art diagnostics, in-patient and out-patient facilities. The service is a designated national centre for the diagnosis and management of severe gut diseases including intestinal pseudo-obstruction. 

Dr Thapar also leads a research team, which is closely integrated with the clinical service. He currently chairs the British Society of Paediatric Gastroenterology Hepatology and Nutrition (BSPGHAN) Gut Motility Disorders Working Group and sat on the BSPGHAN council as research lead. He is the Paediatric (ESPGHAN) representative on the United European Gastroenterology (UEG) ‘Future Trends Committee’. 

Dr Thapar is a member of the sub-specialty clinical studies group of the Medicines for Children Research Network and is involved in the development of clinical research networks across Europe. Dr Thapar is keenly involved in education and is co-executive director of the Academy of Paediatric Gastroenterology. He is on the teaching faculty of ESPGHAN.


Neurogastroenterology and gut motility disorders including: 

  • dysphagia
  • gastro-oesophageal reflux
  • gastroparesis
  • intestinal pseudo-obstruction 
  • Hirschsprung’s disease
  • constipation and functional abdominal pain. 

Other clinical interests include conditions that overlap with gut motility including allergy, metabolic and connective tissue disorders. A programme for novel therapies is being developed.


  • BMBS
  • PhD (University of London)
  • MRCP (UK)
Nikhil Thapar undertook his undergraduate medical training at Southampton University. He went on to complete his MRCPCH and postgraduate Paediatric training in the Wessex region and thereafter his subspecialist training in Paediatric Gastroenterology in London. He has a particular interest in neurogastroenterology and gut motility disorders and has completed a PhD at the National Institute for Medical Research, London studying the therapeutic potential of stem cells for gut motility disorders. Following completion of the PhD in 2004 (University of London), he was awarded a Clinician Scientist post at the UCL Institute of Child Health and subsequently a Senior Lectureship. In 2006 was appointed as honorary consultant in Paediatric Gastroenterology at Great Ormond Street Hospital.

Research Interests

Dr Thapar leads a research programme studying the pathogenesis and treatment of gut motility disorders with a particular focus on improving diagnosis, understanding the molecular and genetic mechanisms underlying such disorders as well as the developing novel therapies including stem cells and gut tissue engineering. The team have been responsible for improved diagnostics and have made significant progress in the understanding of normal and aberrant development of the enteric neuro-musculature and development of stem cell therapies for gut disease.

Recent publications

High-resolution colonic manometry accurately predicts colonic neuromuscular pathological phenotype in pediatric slow transit constipation 
Giorgio V, Borrelli O, Smith VV, Rampling D, Köglmeier J, Shah N, Thapar N, Curry J, Lindley KJ.
Neurogastroenterol Motil. 2012 Oct 3. doi: 10.1111/nmo.12016.

Cow's milk challenge increases weakly acidic reflux in children with cow's milk allergy and gastroesophageal reflux disease 
Borrelli O, Mancini V, Thapar N, Giorgio V, Elawad M, Hill S, Shah N, Lindley KJ.
J Pediatr. 2012 Sep;161(3):476-481.e1. doi: 10.1016/j.jpeds.2012.03.002. Epub 2012 Apr 17.

Genetics of human enteric neuropathies 
Panza E, Knowles CH, Graziano C, Thapar N, Burns AJ, Seri M, Stanghellini V, De Giorgio R.
Prog Neurobiol. 2012 Feb;96(2):176-89. Epub 2012 Jan 14.

Clinical picture of intestinal pseudo-obstruction syndrome 
Thapar N.
J Pediatr Gastroenterol Nutr. 2011 Dec;53 Suppl 2:S58-9.

Advances in enteric neurobiology: how close are we to clinical use? 
Hotta R, Thapar N.
J Pediatr Gastroenterol Nutr. 2011 Dec;53 Suppl 2:S43-5.

Gastrointestinal endoscopy and mucosal biopsy in the first year of life: indications and outcome 
Volonaki E, Sebire NJ, Borrelli O, Lindley KJ, Elawad M, Thapar N, Shah N.
J Pediatr Gastroenterol Nutr. 2012 Jul;55(1):62-5.

Stem cells for GI motility disorders 
Hotta R, Natarajan D, Burns AJ, Thapar N.
Curr Opin Pharmacol. 2011 Dec;11(6):617-23. Epub 2011 Nov 4.

Variants in RET associated with Hirschsprung's disease affect binding of transcription factors and gene expression 
Sribudiani Y, Metzger M, Osinga J, Rey A, Burns AJ, Thapar N, Hofstra RM.
Gastroenterology. 2011 Feb;140(2):572-582.e2. Epub 2010 Oct 25.



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