Episode 1: 'Fix My Genes'

The first episode of the BBC documentary series Great Ormond Street follows three Great Ormond Street Hospital (GOSH) patients who undergo a mix of bone marrow transplantation and pioneering gene therapy to treat their rare conditions.

GOSH is a world-leading paediatric centre for the treatment of rare diseases, 75 per cent of which affect children. One in 17 people will suffer from a rare disease at some point in their lives, and 30 per cent of patients will die before their fifth birthday.

Read more about the patients featured in the episode, and the specialists who treat them, below, and find out how you can help.

The patients

Keano and his mum
Keano

At just three years old, Keano and his mum left their home in Zimbabwe to have treatment in the UK for his severe congenital neutropenia. Individuals with this rare condition lack neutrophils – a type of white blood cell in the bone marrow which fights infection – which makes them prone to recurrent infections.

Keano had a bone marrow transplant at GOSH after seven years of searching for a donor match.

Read Keano's story

GOSH patient Herb
Herb

Six-year-old Herb had a bone marrow transplant at GOSH after being diagnosed with a rare syndrome called NEMO deficiency, which affects his immune system. 

Getting a final diagnosis was a lengthy process as Herb's disease is so rare.

Specialists also found Herb had a previously undocumented gene mutation, making his condition new territory for everyone involved.

Read Herb's story

Teigan
Teigan

Eleven-year-old Teigan was diagnosed with severe combined immunodeficiency (SCID) as a baby.

Using a pioneering treatment called gene therapy, specialists at GOSH have extracted Teigan's faulty genes and replaced them with working ones to treat her rare disease.

Read Teigan's story

The clinicians

Paul Veys - BBC series 3
Paul Veys

Paul has been Director of the Bone Marrow Transplant Unit at GOSH since 1994. He specialises in stem cell transplant for primary immunodeficiencies and reduced intensity stem cell transplant in paediatric diseases.

Paul is married to Dr Catherine M Owens, Consultant Radiologist at GOSH, and the couple have three children.

Read more about Paul's work

Bobby Gaspar
Bobby Gaspar

Bobby is an expert in paediatrics and immunology at GOSH and the UCL Institute of Child Health. His time is split between seeing patients in the hospital and developing new gene therapy treatments for complex diseases of the immune system in the laboratory.

Bobby has a wife and three daughters and likes taking on cycling challenges in his spare time.

Read more about Bobby's work

Professor Persis Amrolia
Persis Amrolia

Persis specialises in haematology and bone marrow transplant, working in the Bone Marrow Transplant Unit at GOSH.

He spends half of his time looking after children undergoing bone marrow transplant, and half of his time on research.

Outside of GOSH, Persis has a keen interest in astronomy and cricket. He is married to a children's book illustrator and has one daughter.

Read more about Persis' work

Kanchan Rio
Kanchan Rao 

Kanchan came to GOSH in 1999 as a Registrar in Haemato-oncology.
She specialises in paediatric bone marrow transplant.

Married with two children, Kanchan's interests outside of work include Zumba, Indian music and cooking.

Read more about Kanchan's work