Clinical guidelines

Clinical guidelines are used by the health professionals at Great Ormond Street Hospital for a wide range of conditions, treatments and tests.

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Clinical guidelines

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Coagulation factors

Coagulation factors are proteins, which in the blood, cause clotting. The factors are manufactured either from human blood (plasma derived) or genetic engineering (recombinant). Advice should be sought from a Consultant Haematologist prior to any decision to prescribe and administer coagulation factors.

Ketogenic diet

The ketogenic diet (KD) is a therapeutic diet, which has been shown to improve seizure control in patients with drug resistant epilepsy, and is used in some patients with metabolic conditions for example, glucose transporter type 1 deficiency syndrome (GLUT1) and pyruvate dehydrogenase deficiency (PDH).

NOTE: We review our guidelines regularly and this guideline is now past its review date. The content of the guideline below may not reflect the most recent evidence based practice. Please use with caution.

The decision to withdraw or withhold life-sustaining treatment for children and young people in Intensive Care Units: guidance for nurses

The decision to withdraw or withhold life-sustaining treatment in paediatric and neonatal intensive care units (ICUs) is both complex and emotive for everyone involved.

All members of the treating healthcare team, led by the consultant in charge, should be involved in the decision-making process.This guideline is intended to be used by nurses when situations arise where it may be ethical and legal to consider withholding or withdrawing life-sustaining medical treatment.