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GOSH awarded £37 million funding to carry out pioneering paediatric research

The NIHR Great Ormond Street Biomedical Research Centre (BRC) has been awarded £37 million in funding to drive forward translational research into rare diseases in children. The Centre is the only one of its kind in the UK dedicated to paediatric research.

Researchers announce oesophagus regeneration trial

A team led by Professor Paolo De Coppi has announced that they are set to build and transplant an oesophagus using organs harvested from pigs and then modified using a child’s stem cells. The organs will be created for children who are born with a severe cases of oesophageal atresia, where their oesophagus has not formed properly. 

Role of important protein improves understanding of autoimmune diseases

Researchers – led by Great Ormond Street BRC-supported Professor Tessa Crompton in collaboration with the Paediatric Department at Oxford University – have identified the role of a key protein in normal development of the thymus, an important organ of the immune system. 

Cannabidiol trial shows reduction in seizures for children with Dravet syndrome

A trial conducted in Europe and the USA has shown that cannabidiol – a drug derived from cannabis but with the psycho-active elements removed – reduces seizures in children with a form of drug resistant epilepsy, known as Dravet syndrome.

Accelerated approval request for a new drug for a rare childhood muscle disorder

A drug for Duchenne Muscular Dystrophy (DMD), originally developed by BRC Theme Lead Professor Francesco Muntoni’s Consortium in the UK, has been filed by Sarepta Therapeutics for accelerated approval by the United States Food and Drug Adminstration (FDA).

Trial suggests no adverse effects of vaginal progesterone prophylaxis for the prevention of preterm birth on child at age two

Diagnostics and Imaging Theme Lead Professor Neil Sebire has teamed up with researchers from nine other establishments to carry out the largest randomised trial to investigate the long-term safety of vaginal progesterone prophylaxis for preterm births.

International Nurses Day: Q and A with our Chief Nurse, Juliette Greenwood

Friday 12 May is International Nurses Day and across the world, the global health family comes together to celebrate the nursing profession. This year the theme focuses on ‘nurses as heroes’ and here at Great Ormond Street Hospital (GOSH) we want to pay tribute and say thank you to all our nursing staff who we see as the superheroes of healthcare. 

Professor Neil Sebire receives grant to investigate the potential use of the minimally invasive autopsy

Professor Neil Sebire – who is Diagnostics and Imaging Theme lead at the Great Ormond Street BRC has been awarded an NIHR HTA grant on behalf of the Minimally Invasive Autopsy team at Great Ormond Street Hospital.

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