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Research at GOSH

Research can improve children’s lives, offering new ways of treating diseases or developing new medicines. This information sheet from Great Ormond Street Hospital (GOSH) explains about the research we do and how to find out more.


The clinical team at GOSH works closely with the research department at the Behavioural and Brain Sciences Unit (BBSU) at UCL Great Ormond Street Institute of Child Health (ICH). We collaborate with colleagues around the world to try and understand the genetic, psychological and neurophysiological basis of disorders on the autism spectrum. All information we obtain in terms of interview, observation and other investigations is compiled into anonymised computerised files. From our database of nearly 2000 children, we are able to compare a child’s problems with others seen in our clinic and can look for similarities and differences. For research purposes, we usually ask parents to donate DNA samples too. 

Research (FDT)

Our current research and development projects include the following:

  • A project to identify the main problem areas and issues related to feeding difficulties in children most relevant to include in parent/carer groups
  • Development and evaluation of a tube weaning protocol
  • Collaboration in a study designed to test how good the DAWBA (Development and Well-Being Assessment) is at identifying problems in children in the community and children seen in clinics (with Prof Tamsin Ford and Prof Robert Goodman)
  • Design and development of a clinical assessment measure for Avoidant Restrictive Food Intake Disorder (with Kamryn Eddy and Jennifer Thomas, Boston, USA)


The Dietetics department works closely with many clinical teams in the hospital where nutrition, growth and development may be an issue.

Research and publications

The cleft team has a long history of clinical research and audit activity.  It is a multi-disciplinary service and the contributions have been from speech and language therapists, psychologists, audiological physicians, orthodontists, paediatricians, as well as surgeons.