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Intrathecal methotrexate

Intrathecal methotrexate is a chemotherapy drug which is given to prevent leukaemia cells entering the cerebrospinal fluid (CSF) around the spine and brain. This drug is also used to treat leukaemia found in the CSF. This page from Great Ormond Street Hospital (GOSH) describes intrathecal methotrexate, how it is given and some of the possible side effects.

Administration of Non-Cytotoxic Medication via an Intracerebroventricular Reservoir

The purpose of this document is to provide guidance for the administration of non-cytotoxic injection or infusion via an Intracerebroventricular (ICV) reservoir at Great Ormond Street Hospital (GOSH). 

This guideline is to be used for the administration of cerliponase alfa/BMN190 and may need to be adapted for administration of other ICV medications. 

For intrathecal or ICV administration of cytotoxic drugs please see the clinical guideline; Intrathecal cytotoxic chemotherapy: administration via a lumbar puncture or Ommaya reservoir.

Opsoclonus myoclonus syndrome / dancing eye syndrome (OMS/DES)

Opsoclonus myoclonus syndrome (OMS), also known as dancing eye syndrome (DES) or Kinsbourne syndrome, is a rare neurological condition which develops over days or weeks in early childhood. This information sheet from Great Ormond Street Hospital (GOSH) explains the causes, symptoms and treatment of opsoclonus myoclonus syndrome and where to get help.

Multiple sclerosis

When young people are told that they have a diagnosis of multiple sclerosis (MS) they usually have lots of questions. Some young people may have never heard of the condition and most will never have met anybody else who has this condition. It can be difficult to know where to look for information and how to find answers to their questions.