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Immunoglobulin therapy

This booklet has been produced by the PID UK Medical Advisory Panel and Patient Representative Panel in conjunction with Great Ormond Street Hospital and the Great North Children’s Hospital. It provides information on immunoglobulin therapy (Ig therapy) to help answer the questions parents may have about this form of treatment for children and young people affected by primary immunodeficiency (PID).The information should not, however, replace advice from a clinical immunologist.

Skin biopsy: punch method

The skin is complex with an array of functions. It is the body’s largest organ, protecting the deeper tissues and organs from mechanical damage, chemical damage, bacterial damage, ultraviolet radiation and thermal damage. The skin aids in regulating body temperature, in excretion of urea and uric acid and also synthesis of vitamin D (Marieb 2012). 

Iloprost

Iloprost is known as a prostaglandin. It acts by imitating a naturally occurring substance in the body called prostacyclin. It is prescribed at GOSH to treat pulmonary hypertension (high blood pressure in the blood vessels in the lungs). It works by lowering blood pressure by widening the blood vessels in the lungs.

Administration of Non-Cytotoxic Medication via an Intracerebroventricular Reservoir

The purpose of this document is to provide guidance for the administration of non-cytotoxic injection or infusion via an Intracerebroventricular (ICV) reservoir at Great Ormond Street Hospital (GOSH). 

This guideline is to be used for the administration of cerliponase alfa/BMN190 and may need to be adapted for administration of other ICV medications. 

For intrathecal or ICV administration of cytotoxic drugs please see the clinical guideline; Intrathecal cytotoxic chemotherapy: administration via a lumbar puncture or Ommaya reservoir.

Extravasation and infiltration

This guideline covers the recognition, management and prevention of infiltration and extravasation injury.

NOTE: We review our guidelines regularly and this guideline is now past its review date. The content of the guideline below may not reflect the most recent evidence based practice. Please use with caution.

Tracheal resection

Tracheal resection is an operation on the windpipe – the tube which connects the voicebox to the lungs. It involves a short section of the windpipe being removed and the cut ends of the windpipe are stitched back together.

Propranolol for headaches

Propranolol belongs to a group of drugs called beta blockers. It is used in patients with heart problems to control high blood pressure or irregular heart beats. It is also used to treat certain types of vascular birthmarks. It is also used to prevent migraines and headaches.

Tendon sheath injections

Tendon sheath injections are suggested when the tissues around a tendon are painful, swollen or difficult to move. Tendon sheath injections on their own are unlikely to offer a cure, but can be helpful alongside other treatments such as physiotherapy, splinting and other longer term medicines.

Head injuries

Head injuries may involve the scalp, the skull, the brain or its protective membranes.This page from Great Ormond Street Hospital (GOSH) explains the effects that a head injury can have on a child. It also sets out the treatment and care of any complications following a head injury.