Intrathecal methotrexate is a chemotherapy drug which is given to prevent leukaemia cells entering the cerebrospinal fluid (CSF) around the spine and brain. This drug is also used to treat leukaemia found in the CSF. This page from Great Ormond Street Hospital (GOSH) describes intrathecal methotrexate, how it is given and some of the possible side effects.
Methotrexate is a medicine that has been used to treat chronic inflammatory conditions such as juvenile idiopathic arthritis, juvenile dermatomyositis, systemic lupus erythematosus, vasculitis and severe psoriasis for many years.This information sheet from Great Ormond Street Hospital (GOSH) explains about the use of methotrexate in such conditions.
Rituximab (brand name MabThera®) is a relatively new medicine which works on the immune system. It removes some of the white blood cells in the body which are called B cells. Removing these stops the production of antibodies that may play a role in your child’s illness.
This guideline covers obtaining blood samples from intermediate to long-term central venous access devices at Great Ormond Street Hospital (GOSH).
NOTE: We review our guidelines regularly and this guideline is now past its review date. The content of the guideline below may not reflect the most recent evidence based practice. Please use with caution.
Parry-Romburg syndrome (also known as Progressive Hemifacial Atrophy) is a rare condition affecting the skin and soft tissues on one side of the face (hemifacial). This information sheet from Great Ormond Street Hospital (GOSH) explains the causes, symptoms and treatment of Parry-Romburg syndrome and where to get help.