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UCL film on potential of amniotic stem cells

3 October 2011

Research experiment
UCL is promoting Stem Cell Awareness Day (5th October) with a video on YouTube of surgeon Paolo de Coppi and colleagues. The video is the work of of the UCL Centre for Stem Cells and Regenerative Medicine.

http://youtu.be/qD_V1hqR6SI

Stem cells have the capacity to become other types of cell. Mr de Coppi has looked for naturally occurring stem cells fluid as a novel solution to some of the serious birth defects he sees. Around 40 per cent of patients at Great Ormond Street Hospital (www.gosh.nhs.uk) have some form of birth defect.

Mr de Coppi said “As a surgeon I often see the devastating effects of multiple reconstructive operations aimed at replacing damaged organs. I have therefore focused my research interests on stem cells and tissue engineering, trying to find new ways to treat complex birth defects. I have identified stem cells in the amniotic fluid [1] and found they have the ability to become many different types of cell.  Our research aims to find ways of using these cells to repair and replace damaged tissues, so that babies are given the chance of a healthy life from the day they are born.”

“The idea is we can create tissues in a test tube using a baby’s own cells, and then implant these at birth. We’re looking at repairing organs like intestines or windpipes. Grown from a child’s own cells, there should be no rejection of tissue.”

Mr de Coppi’s work is supported by Great Ormond Street Hospital Children’s Charity (www.gosh.org).

The video featuring Paolo De Coppi's work was produced and coordinated by the UCL Centre for Stem Cells and Regenerative Medicine, http://www.ucl.ac.uk/stemcells/   The Centre brings together 185 research groups across UCL and partners  with a common interest in all aspects of stem cells, tissue engineering, repair and regeneration and the development of their therapeutic and biotechnological potential.

[1]  the intention is to obtain samples of the stem cells in the fluid surrounding an unborn baby, without harming the baby

[2] Mr de Coppi is also involved in the team who used blood stem cells to grow the tissue surrounding a donor windpipe (/news/press-releases/2010-press-release-archive/world-first-transplant-in-child/)

Contact information:

GOSH-ICH Press Office: 020 7239 3125
Email: Coxs@gosh.nhs.uk
For genuine and urgent out of hours call speak to switchboard on 020 7405 9200

Notes to editors

Great Ormond Street Hospital for Children NHS Trust is the country’s leading centre for treating sick children, with the widest range of specialists under one roof.

With the UCL Institute of Child Health, we are the largest centre for paediatric research outside the US and play a key role in training children’s health specialists for the future.

Our charity needs to raise £50 million every year to help rebuild and refurbish Great Ormond Street Hospital, buy vital equipment and fund pioneering research. With your help we provide world class care to our very ill children and their families.