We're pleased to confirm a grant from the Neuroblastoma Society to Dr
Arturo Sala, University College of London Institute of Child Health.
Re-activating ApoJ/clusterin expression as a novel therapeutic approach
for neuroblastoma. This study takes aims to propose to understand
the precise mechanism by which MYCN (a gene implicated in
aggressive neuroblastoma) downregulates the ApoJ/clusterin gene, and
whether reactivating ApoJ/clusterin inhibits neuroblastoma development.
so-called "epigenetic" drugs are already approved for use in adults so
success with the project could pave the way to their use for children
with aggressive neuroblastomas."
DR Sala said "I'm grateful to
the Neuroblastoma Society for backing this important work. Aggressive
neuroblastoma can be one of the most difficult cancers to treat in
children and new therapeutic approaches are needed."
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