Stephen Marks

Dr Stephen Marks is a Consultant Paediatric Nephrologist and Clinical Lead for renal transplantation at Great Ormond Street Hospital (GOSH). 

This is the largest kidney transplantation unit in the United Kingdom for children. He currently chairs the National Organisation of Paediatric Renal Transplantation in the UK (NHSBT Paediatric Kidney Advisory Group).

"I love seeing how we are able to improve the quality of life for our patients on dialysis after they receive a good functioning kidney transplant. I love looking after the patients for many years and seeing them throughout their childhood and growing up into young adults! I love working with members of our team as we all aim to improve the long term outcomes of our patients."

Dr Stephen Marks

Specialisms

  • renal transplantation

  • systemic lupus erythematosus

  • vasculitis

  • hypertension

Qualifications and training

  • MBChB (Glasgow) 10 July 1993

  • MRCP (UK) 25 March 1996

  • DCH (London) 16 April 1996 

  • MRCPCH 1 March 1998.

  • MSc in Clinical Paediatrics (UCL) 1 November 2000 (Four distinctions)

  • FRCPCH 1 March 2005

  • MD (University of London) 31 May 2008

Committees:

  • 2011 - Chair of the National Health Service Blood and Transplant (NHSBT) Paediatric Kidney Advisory Group
  • 2011 - Chair of the International Pediatric Transplant Association (IPTA) Publications and Communications Committee
  • 2011 - British Association for Paediatric Nephrology (BAPN) representative for NHSBT Kidney Advisory Group
  • 2008 - Member of RaDaR MPGN group (UK Registry for Rare Kidney Diseases - (Membranoproliferative Glomerulonephritis) 

Editorial boards:

2010 - Associate Editor of:

  • Pediatric Transplantation, the journal of the International Pediatric Transplant Association (IPTA)

  • Pediatric Nephrology, the journal of the International Pediatric Nephrology Association (IPNA)

Memberships

1. Paediatric (and adult) nephrology and transplantation groups including:

  • Renal Association

  • British Transplantation Society

  • Royal College of Paediatrics and Child Health;

  • British Association for Paediatric Nephrology

  • European Society for Paediatric Nephrology

  • International Pediatric Nephrology Association

  • International Pediatric Transplant Association

  • International Pediatric Hypertension Association

  • International Society of Nephrology

2) Other organisations:

  • General Medical Council

  • British Medical Association

  • Medical Defence Union

Research interests

His research continues to date in the fields of:

1. Renal transplantation including collaborative research of urine, blood and MRI biomarker studies, innovative drug trials concerning new anti-rejection therapies and assessment of children post-renal transplantation, including development of allergies.

2. Systemic lupus erythematosus (SLE) and vasculitis research into the aetiopathogenesis, management and outcome of childhood onset lupus nephritis at various levels:

  • (i) Locally (currently co-supervising MD student into cardiovascular morbidity in children and young people with SLE).
  • (ii) Nationally (cohort study and repository of UK JSLE study group).
  • (iii) European (paediatric nephrology expert for the joint European League Against Rheumatism and European Renal Association - European Dialysis and Transplant Association (EULAR/ERA-EDTA) recommendations for the management of adult and paediatric lupus nephritis).
  • (iv) Internationally (UK Chief Investigator for the international SMILEY (Simple Measure of the Impact of Lupus Erythematosus in Youngsters) study developing a novel, valid and reliable health-related quality of life tool for children with systemic lupus erythematosus.

3. Renovascular hypertension including genetic linkage and familial studies of renovascular hypertension and clinical studies on the management and long-term prognosis of children with renovascular hypertension. 

Publications

Marks SD. New immunosuppressants in pediatric solid organ transplantation. Curr Opin Organ Transplant 2012; 17(5): 503 - 508.

Harden PN, Walsh G, Bandler N, Bradley S, Lonsdale D, Taylor J, Marks SD. Bridging the gap: an integrated paediatric to adult clinical service for young adults with kidney failure. BMJ 2012; 344: e3718 (published in print on 16 June 2012; 344 (7861): 51 - 55).

Marks SD, Tullus K. Autoantibodies in systemic lupus erythematosus. Ped Nephrol 2012; 27(10): 1855 - 1868.

Mencarelli F, Marks SD. Non-viral infections in children after renal transplantation. Ped Nephrol 2012; 27(9): 1465 - 1476.

Marks SD, Gullett AM, Brennan E, Tullus K, Jaureguiberry G, Klootwijk E, Stanescu H, Kleta R, Woolf AS. Renal FMD may not confer a familial hypertensive risk nor is it caused by ACTA2 mutations. Ped Nephrol 2011; 26(10): 1857 - 1861.

Sinha R., Saad A, Marks SD. Prevalence and complications of chronic kidney disease in paediatric renal transplantation: a K/DOQI perspective. Nephrol Dial Transplant 2010, 25: 1313-1320.

Marks SD, Shah V, Pilkington C, Tullus K. Urinary monocyte chemoattractant protein-1 correlates with disease activity in lupus nephritis. Ped Nephrol 2010; 25(11): 2283 - 2288.