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Food intolerance 

Food intolerance is a type of food hypersensitivity that is very different to food allergy. Food allergy and food intolerance are often confused. A food allergy provokes a response from the immune system, but food intolerance does not.

Freeman-Sheldon syndrome

This page from Great Ormond Street Hospital (GOSH) explains the causes, symptoms and treatment of Freeman Sheldon syndrome (previously known as Whistling Face syndrome) and where to get help. Freeman-Sheldon syndrome is a rare genetic condition that affects the mouth, face, hands and feet.


Gallstones are stone-like formations found in the gallbladder. They can vary significantly in size, shape and consistency, and they can be present without causing any problems at all. This information sheet from Great Ormond Street Hospital (GOSH) explains about gallstones, what causes them and how they can be treated using an operatoin to remove the gall bladder (laparoscopic cholecystectomy).

Gastro-oesophageal reflux

When a baby or child has gastro-oesophageal reflux, the food and drink travels down the foodpipe as normal. However, some of the mixture of food, drink and acid travels back up the foodpipe, instead of passing through to the large and small intestines. As the food and drink is mixed with acid from the stomach, it can irritate the lining of the foodpipe, making it sore. This is gastro-oesophageal reflux disease.

Generalised lymphatic anomaly (GLA)

Generalised lymphatic anomaly (GLA) – previously known as lymphangiomatosis – is the name given to a rare, congenital (present at birth), and progressive disorder of lymphatic channels which can affect different organs including the bones and the intestines. It can cause problems if the abnormal lymphatic tissue develops within important tissues and structures. This information sheet from Great Ormond Street Hospital (GOSH) explains the causes, symptoms and treatment of generalised lymphatic anomalies (GLA) and where to get help. 

Genetic aspects of primary immunodeficiency

This booklet has been produced jointly between PID UK, Great Ormond Street Hospital (GOSH) and the Great North Children’s Hospital. It is designed to help answer the questions that families may have about the genetic aspects of primary immunodeficiencies (PID). The information has been reviewed by the PID UK Medical Advisory Panel and Patient Representative Panel and by families affected by PID but should not replace advice from a clinical immunologist or a geneticist.